Cognitive & Mood Not FDA-approved · research compound

RG3

Ginsenoside Rg3 · 20S-Ginsenoside Rg3

Evidence: Studied in humans. Example dose: finalize with a provider. Not a fact-check stamp.

Per compounding pharmacy protocol SubQ 1x daily

1-2 sprays per nostril Nasal Daily

Ginsenoside Rg3 is a tetracyclic triterpenoid saponin found in Panax ginseng (Asian ginseng). It is one of the most pharmacologically active ginsenosides and is present in very low concentrations in raw ginseng but becomes enriched during steaming/processing (red and black ginseng). Rg3 exists in two stereoisomers - 20(S)-Rg3 and 20(R)-Rg3 - which have somewhat different biological activities. The 20(S) form is more commonly studied.

Quick Start

Route

Subcutaneous (SubQ)

Start low

Per compounding pharmacy pr… SubQ

Frequency

1x daily

Timing

No specific requirement

Starting dose. Per compounding pharmacy protocol

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Conservative start

Per compounding pharmacy protocol · Subcutaneous (SubQ) · 1x daily

conservative starter

Per compounding pharmacy protocol

1x daily

Standard

Neuro-Inflammation Intranasal

1-2 sprays per nostril · Nasal · Daily

in vitro · Bae et al. 2006 (Planta Med)

Often compounded with NAD+ and Vitamin B12 as a synaptogenic nasal spray. Ginsenoside Rg3 has substantial human trial data, including a 480-patient randomised placebo-controlled trial (NCT01717066), but all of it used oral capsules alongside cancer treatment. No human study has tested intranasal delivery or brain inflammation, so that evidence does not transfer to this card.

1-2 sprays per nostril

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Vials in this mix

Syringe size

Target dose

050100u

Draw to

— units

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I will split this dose across more than one syringe

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How it works

Modulates multiple inflammatory pathways including NF-kB and MAPK signaling, reducing pro-inflammatory cytokine production (TNF-alpha, IL-6, IL-1beta) and oxidative stress.

Enhances insulin sensitivity and glucose metabolism through activation of AMPK and modulation of PI3K/Akt signaling, supporting metabolic health.

Exerts neuroprotective effects through reduction of neuroinflammation, promotion of neuronal survival via BDNF upregulation, and inhibition of amyloid-beta aggregation.

What to expect

Early

Days 1–7

Days 1-7: Subtle changes in energy and inflammation. Effects build gradually.

Evidence

HumanPresent

AnimalPresent

In-vitroPresent

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

Ginsenoside Rg3, as one of the major active components of Panax ginseng, exhibits significant anti-tumor, anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, wound healing and immunomodulatory pharmacological effects and has been developed as an adjuvant therapy in clinical practice.

Ginsenoside Rg3, as one of the major active components of Panax ginseng, exhibits significant anti-tumor, anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, wound healing and immunomodulatory pharmacological effects and has been developed as an adjuvant therapy in clinical practice.

Pharmacological mechanisms and drug delivery systems of ginsenoside Rg3: A comprehensive review. Pharmacological research · 2025 · PMID 40414584

Evidence scope. Review of ginsenoside Rg3; no evidence for a subcutaneous compounded formulation.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: Per compounding pharmacy protocol via Subcutaneous (SubQ), 1x daily. No checked live PubMed abstract supported this complete molecule/formulation/route/dose/frequency combination.

Primary safety claim: Injection site irritation. No checked live abstract directly established this as the primary concern for the card's exact formulation and regimen.

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

Documented together

BPC-157Anti-inflammatory ginsenoside and tissue repair peptide have complementary but non-conflicting mechanisms

EpithalonTelomerase activation and anti-inflammatory support address different biological pathways

MelatoninAntioxidant and circadian support does not conflict with ginsenoside anti-inflammatory activity

Urolithin AMitophagy activation and anti-inflammatory ginsenoside act through independent pathways

Keep separate

Pentosan PolysulfateRG3 has mild antiplatelet activity and PPS has anticoagulant properties - combined use may increase bleeding risk

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

Pharmacokinetics

Illustrative plasma concentration · 16 h

Half-life

~3-4 hours

Variable based on route and formulation

Peak · Tmax

1-3 hours

Oral; 15-30 min SubQ

Elimination

~15-20 hours

Bioavailability

~5-10%

Oral (poor absorption); ~80-90% SubQ

Duration of action

12-24 hours

Anti-inflammatory and metabolic effects persist beyond plasma clearance

Clearance

Hepatic metabolism (CYP enzymes) and biliary excretion

Storage. Store refrigerated at 2-8C. Protect from light.

Regulatory status

Approved as adjunctive cancer therapy in China (Shenyi capsule). Not FDA-approved in the United States. Available through compounding pharmacies as a research compound in Western countries.

Put it to work

Calculate, log & track

Open RG3 straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open RG3 in the app →

Go deeper

The guide & community

The complete RG3 walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

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