OnePin Peptide Library · Cognitive & Mood
PE-22-28
PE22-28 · PE 22-28
PE-22-28 is a synthetic heptapeptide fragment derived from the neuroprotective protein Prohibitin (PHB). It was identified through screening of PHB-derived peptide fragments for anti-aging properties at the cellular level. PE-22-28 enhances cellular stress resistance and has been studied in the context of neuroprotection, anti-aging, and cognitive preservation. It is one of the newer nootropic peptides with limited but intriguing preclinical data.
Any time of day. No fasting required. Often combined with other nootropics.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
PE-22-28 derived from Prohibitin interacts with mitochondrial and nuclear signaling pathways to enhance cellular stress resistance. PHB family proteins are involved in mitochondrial morphogenesis, cell cycle regulation, and transcriptional control. The exact receptor target and signaling pathway for PE-22-28 specifically is less well-characterized than many other peptides in this database.
PE-22-28 derived from Prohibitin interacts with mitochondrial and nuclear signaling pathways to enhance cellular stress resistance. PHB family proteins are involved in mitochondrial morphogenesis, cell cycle regulation, and transcriptional control. The exact receptor target and signaling pathway for PE-22-28 specifically is less well-characterized than many other peptides in this database.
What to expect
Days 1-14: Minimal changes.
Weeks 2-6: Possible cognitive improvements.
Weeks 6+: Cumulative neuroprotective effects.
Evidence
The honest take
Anti-aging nootropic
Prohibitin-derived. Preclinical data supports cellular stress resistance. Very early stage research.
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Side effects & safety
Commonly reported
- Limited data
- Generally reported as well tolerated
Less common & notes
- Minimal adverse event data available.
Pharmacokinetics
Storage. Standard BAC water 2-8C. 28 days.
Regulatory status
Research compound only. Not FDA-approved.
Put it to work
Calculate, log & track
Open PE-22-28 straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open PE-22-28 in the app →Go deeper
The guide & community
The complete PE-22-28 walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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