OnePin Peptide Library · Cognitive & Mood
N-Acetyl Selank Amidate
NA-Selank · N-Acetyl-Selank · Selank Amidate
N-Acetyl Selank Amidate is a modified, more stable version of Selank, a synthetic peptide analogue of the naturally occurring immunomodulatory peptide tuftsin. Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been approved in Russia as an anxiolytic since 2009. The N-acetyl amidate modification protects the peptide from rapid enzymatic degradation, resulting in improved bioavailability and a longer duration of action compared to native Selank.,Selank acts primarily through modulation of the GABAergic and serotonergic systems, and it influences the expression of brain-derived neurotrophic factor (BDNF) and several interleukins. Unlike benzodiazepines, it does not produce sedation, cognitive impairment, or dependence at standard doses. Research has focused on its anxiolytic, nootropic, and immunomodulatory properties.,While Selank is an approved pharmaceutical in Russia, N-Acetyl Selank Amidate specifically remains a research compound outside of Russia. Clinical trials of the parent compound Selank have been conducted in Russian institutions, but Western regulatory agencies have not evaluated or approved either form.
Same as Selank but longer-acting. 1-2 daily doses sufficient. No fasting required.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Modulates GABAergic neurotransmission and enhances the inhibitory effect of GABA, producing anxiolytic effects without sedation or dependence.,Increases expression of brain-derived neurotrophic factor (BDNF) and influences serotonin metabolism, supporting neuroplasticity and mood regulation.,Modulates cytokine expression (IL-6, IL-10) and influences T-helper cell balance, contributing to immunomodulatory effects.
Modulates GABAergic neurotransmission and enhances the inhibitory effect of GABA, producing anxiolytic effects without sedation or dependence.,Increases expression of brain-derived neurotrophic factor (BDNF) and influences serotonin metabolism, supporting neuroplasticity and mood regulation.,Modulates cytokine expression (IL-6, IL-10) and influences T-helper cell balance, contributing to immunomodulatory effects.
What to expect
Days 1-7: Subtle anxiolytic effect, mild improvement in stress tolerance and calmness.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Store refrigerated at 2-8C. Protect from light. Reconstituted solution stable for up to 28 days refrigerated.
Regulatory status
Approved anxiolytic in Russia (as Selank). Not FDA-approved. N-Acetyl Selank Amidate is sold as a research compound in most Western countries.
Put it to work
Calculate, log & track
Open N-Acetyl Selank Amidate straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open N-Acetyl Selank Amidate in the app →Go deeper
The guide & community
The complete N-Acetyl Selank Amidate walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
Join the community ↗