N-Acetyl Selank Amidate
NA-Selank · N-Acetyl-Selank · Selank Amidate
N-Acetyl Selank Amidate is a modified, more stable version of Selank, a synthetic peptide analogue of the naturally occurring immunomodulatory peptide tuftsin. Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been approved in Russia as an anxiolytic since 2009. The N-acetyl amidate modification protects the peptide from rapid enzymatic degradation, resulting in improved bioavailability and a longer duration of action compared to native Selank.
Same as Selank but longer-acting. 1-2 daily doses sufficient. No fasting required.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Modulates GABAergic neurotransmission and enhances the inhibitory effect of GABA, producing anxiolytic effects without sedation or dependence.
Increases expression of brain-derived neurotrophic factor (BDNF) and influences serotonin metabolism, supporting neuroplasticity and mood regulation.
Modulates cytokine expression (IL-6, IL-10) and influences T-helper cell balance, contributing to immunomodulatory effects.
What to expect
Days 1-7: Subtle anxiolytic effect, mild improvement in stress tolerance and calmness.
Evidence
Claims we could not support
No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.
Dose/route: 100-400mcg; Subcutaneous (SubQ); daily. No checked live PubMed abstract verified this exact displayed dose, route, and frequency for the same molecule/formulation and relevant population.
Mechanism: Modulates GABAergic neurotransmission and enhances the inhibitory effect of GABA, producing anxiolytic effects without sedation or dependence.. No checked live PubMed abstract provided an exact-molecule/formulation sentence supporting this source-JSON mechanism claim.
Primary safety claim: Mild fatigue or drowsiness (uncommon). No checked live PubMed abstract directly verified this source-JSON safety claim at the displayed formulation, route, and regimen.
Interactions & stacking
Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.
Documented together
Keep separate
Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.
Pharmacokinetics
Enhanced vs native Selank
SubQ, ~5-10 min intranasal
Enhanced vs native Selank due to N-acetyl amidate modification. SubQ absorption near-complete. Intranasal ~30-40% (partial BBB bypass).
Anxiolytic and cognitive effects
Enzymatic degradation (peptidases; N-acetyl amidate modification slows proteolysis)
Storage. Store refrigerated at 2-8C. Protect from light. Reconstituted solution stable for up to 28 days refrigerated.
Regulatory status
Approved anxiolytic in Russia (as Selank). Not FDA-approved. N-Acetyl Selank Amidate is sold as a research compound in most Western countries.
Put it to work
Calculate, log & track
Open N-Acetyl Selank Amidate straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open N-Acetyl Selank Amidate in the app →Go deeper
The guide & community
The complete N-Acetyl Selank Amidate walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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