Mitopure
Urolithin A (UA) is a natural metabolite produced by gut bacteria from ellagitannins and ellagic acid found in foods such as pomegranates, walnuts, raspberries, and strawberries. It belongs to the urolithin class of dibenzopyranone compounds. Notably, only about 40% of the human population harbors the specific gut microbiome composition needed to efficiently produce Urolithin A endogenously, which has driven interest in direct supplementation.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
Activates the PINK1/Parkin mitophagy pathway, tagging damaged mitochondria for selective autophagy. This clears dysfunctional mitochondria that produce excessive reactive oxygen species (ROS), reducing oxidative stress and allowing mitochondrial biogenesis to replenish the pool with healthy organelles.
Upregulates genes involved in mitochondrial biogenesis (PGC-1alpha, TFAM) and oxidative phosphorylation, resulting in a net improvement in mitochondrial quality and cellular energy production capacity.
Demonstrates anti-inflammatory effects by reducing circulating biomarkers including C-reactive protein (CRP) and specific acylcarnitines associated with incomplete fatty acid oxidation. Also modulates the NLRP3 inflammasome pathway.
Days 1-14: Mitophagy pathways activated at the cellular level. No subjective effects expected. UA achieves steady-state plasma levels within days.
Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.
Exact-molecule evidence boundary: the live abstract reports the quoted finding for Urolithin A; no broader inference is made.
Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging1.
Evidence scope. Exact molecule wording appears in the quoted live sentence. Only the population/model, formulation, route, and outcome expressly stated there are supported.
Claims we could not support
No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.
Dose/route: 500-1000mg; Oral; daily. No selected live abstract sentence verified this complete regimen.
Mechanism as written in source JSON. No selected live abstract sentence verified the complete mechanism at the card formulation/route and relevant population/model.
Primary safety claim as written in source JSON. No selected live abstract sentence verified the complete safety claim for this exact formulation and route.
Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.
Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.
Oral
~5x half-life
Variable oral (gut microbiome dependent; direct supplementation bypasses conversion)
Mitophagy activation persists; daily dosing maintains continuous mitochondrial recycling
Hepatic (glucuronidation and sulfation); renal excretion of conjugates
Storage. Store at room temperature in a cool, dry place. No refrigeration needed for oral supplement forms. Protect from heat and moisture.
FDA GRAS status as a dietary ingredient (2020). Sold as a supplement (Mitopure by Amazentis/Timeline Nutrition). Not a drug - no FDA drug approval. Novel food status in the EU.
Put it to work
Open Urolithin A straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Urolithin A in the app →Go deeper
The complete Urolithin A walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
Join the community ↗Track it in OnePin. Log vials, draws, and protocols in the app.
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