OnePin Peptide Library · Hormonal
Pregnenolone
Preg
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, primarily in the adrenal glands, brain, liver, and gonads. It is the precursor to virtually all other steroid hormones, including DHEA, progesterone, cortisol, estrogen, and testosterone. Because of this central role, it is sometimes referred to as the 'mother of all hormones' or the 'master steroid.',Beyond its role as a hormone precursor, pregnenolone is itself a potent neurosteroid. It modulates GABA-A and NMDA receptors in the brain, influencing memory, mood, and cognitive function. Pregnenolone levels decline significantly with age - by age 75, levels may be 60% lower than at age 35 - and this decline has been associated with cognitive changes and mood disturbances.,Pregnenolone is available as an over-the-counter dietary supplement in the United States. It is also prescribed by physicians as part of hormone optimization protocols, particularly in cases of adrenal insufficiency or as a complement to other hormone replacement therapy. While it has a long history of use and a good safety profile at standard doses, large-scale clinical trials are limited.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Serves as the biosynthetic precursor to all major steroid hormones via enzymatic conversion: to progesterone (via 3-beta-HSD), to DHEA (via CYP17A1), and subsequently to downstream androgens, estrogens, and corticosteroids.,Acts as a neurosteroid that positively modulates NMDA receptor activity (enhancing excitatory neurotransmission and memory) while negatively modulating GABA-A receptors (providing mild alerting and mood-elevating effects).,Enhances myelination and neuronal membrane stability in the central nervous system, supporting nerve signal conduction and potentially neuroprotective processes.
Serves as the biosynthetic precursor to all major steroid hormones via enzymatic conversion: to progesterone (via 3-beta-HSD), to DHEA (via CYP17A1), and subsequently to downstream androgens, estrogens, and corticosteroids.,Acts as a neurosteroid that positively modulates NMDA receptor activity (enhancing excitatory neurotransmission and memory) while negatively modulating GABA-A receptors (providing mild alerting and mood-elevating effects).,Enhances myelination and neuronal membrane stability in the central nervous system, supporting nerve signal conduction and potentially neuroprotective processes.
What to expect
Days 1-7: Mild improvements in mood, clarity, and well-being. Some users notice effects within the first few days.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Store at room temperature in a cool, dry place. Oral compound - no reconstitution needed.
Regulatory status
Available over-the-counter as a dietary supplement in the United States. Prescription required in many other countries. Not FDA-approved for any specific medical condition.
Put it to work
Calculate, log & track
Open Pregnenolone straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Pregnenolone in the app →Go deeper
The guide & community
The complete Pregnenolone walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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