OnePin Peptide Library · Hormonal
Maca
Maca Root · Lepidium meyenii
Maca (Lepidium meyenii) is a Peruvian root vegetable from the Andes mountains, traditionally consumed for energy, fertility, and libido support. Multiple color phenotypes exist: yellow (most common, balanced effects), red (predominantly studied for prostate health), and black (predominantly studied for energy and male fertility).
Morning common; some users split AM/PM. Avoid evening if energizing effect.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Maca's effects do NOT come from direct hormonal modulation:
Hormonal Neutrality
Multiple controlled studies show maca does NOT increase serum testosterone, estradiol, FSH, or LH levels. The libido and energy effects occur via different pathways.
Macamides
Unique fatty acid amides found in maca that act on cannabinoid (CB1) and TRPV1 receptors. May mediate libido, mood, and adaptogen effects.
Hypothalamic-Pituitary Effects
May modulate HPA and HPG axes at the hypothalamic level rather than peripherally.
Sperm Parameters
In male fertility, maca improves sperm count and motility through unclear mechanisms - likely involves mitochondrial energy metabolism in sperm.
Color Phenotype Differences
Red maca shows specificity for prostate health; black maca for male fertility/energy; yellow is balanced. Likely reflects differential bioactive content.
What to expect
Days 1-14: subtle subjective effects.
Weeks 2-8: peak libido and energy effects.
Weeks 8+: sustained effects; sperm parameter improvements need 12+ weeks.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Keep separate
Side effects & safety
Commonly reported
- Mild GI upset (especially raw maca)
- Mild stimulant effect
Less common & notes
- Goitrogenic compounds in raw maca may affect thyroid at very high doses - cooking/gelatinization eliminates concern.
- Allergic reactions rare.
- Long-term safety good per traditional Andean dietary use.
Pharmacokinetics
Storage. Powder/capsule. Cool, dry location. Sealed container.
Regulatory status
Dietary supplement (US, DSHEA). Traditional food in Peru.
Put it to work
Calculate, log & track
Open Maca straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Maca in the app →Go deeper
The guide & community
The complete Maca walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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