OnePin Peptide Library · Hormonal
DHEA
Dehydroepiandrosterone
Dehydroepiandrosterone (DHEA) is a naturally occurring steroid hormone produced primarily by the adrenal glands, with smaller amounts made by the gonads and brain. It is the most abundant circulating steroid hormone in the human body and serves as a precursor to both androgens (testosterone, dihydrotestosterone) and estrogens (estradiol, estrone). DHEA levels peak in the mid-20s and decline progressively with age, falling by approximately 80% by age 70-80.,DHEA is available as an over-the-counter dietary supplement in the United States under DSHEA (Dietary Supplement Health and Education Act). It has been studied for a wide range of conditions including adrenal insufficiency, aging, sexual dysfunction, depression, osteoporosis, and immune function. The evidence base is mixed, with the strongest data supporting its use in adrenal insufficiency and as a component of fertility treatments.,One specific formulation of DHEA (prasterone/Intrarosa) has received FDA approval as a vaginal insert for the treatment of dyspareunia (painful intercourse) in postmenopausal women due to vulvovaginal atrophy. Oral DHEA supplementation remains classified as a dietary supplement, not a drug, in the US. It is classified as a controlled substance or prescription medication in some other countries including Australia and Canada.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Serves as a biosynthetic precursor that is enzymatically converted to androgens (via 17beta-HSD and 5alpha-reductase) and estrogens (via aromatase) in peripheral tissues through intracrine mechanisms, allowing tissue-specific hormone production.,Directly activates sigma-1 receptors in the brain, which modulate NMDA receptor activity, neurosteroid signaling, and may contribute to neuroprotective and mood-enhancing effects independent of sex hormone conversion.,May modulate immune function through effects on T-cell and NK cell activity, shifting the balance from cortisol-dominant (catabolic/immunosuppressive) toward a more anabolic and immunocompetent state.
Serves as a biosynthetic precursor that is enzymatically converted to androgens (via 17beta-HSD and 5alpha-reductase) and estrogens (via aromatase) in peripheral tissues through intracrine mechanisms, allowing tissue-specific hormone production.,Directly activates sigma-1 receptors in the brain, which modulate NMDA receptor activity, neurosteroid signaling, and may contribute to neuroprotective and mood-enhancing effects independent of sex hormone conversion.,May modulate immune function through effects on T-cell and NK cell activity, shifting the balance from cortisol-dominant (catabolic/immunosuppressive) toward a more anabolic and immunocompetent state.
What to expect
Weeks 1-2: DHEA-S serum levels rise measurably. Subjective effects are typically minimal in this period.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Store at room temperature in a cool, dry place. Oral compound - no reconstitution needed.
Regulatory status
OTC dietary supplement in the United States under DSHEA. Prasterone (Intrarosa) vaginal insert is FDA-approved for dyspareunia. DHEA is a prescription or controlled substance in Australia, Canada, and several European countries. Banned by WADA in competitive sports.
Put it to work
Calculate, log & track
Open DHEA straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open DHEA in the app →Go deeper
The guide & community
The complete DHEA walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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