GnRH (Gonadorelin)
Gonadorelin · GnRH · Lutrelef · Cystorelin · Factrel
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH) produced by the hypothalamus. It binds to GnRH receptors on the anterior pituitary gland, stimulating the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These gonadotropins are essential for reproductive function, stimulating testosterone production in males and ovulation in females.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Binds to GnRH receptors on anterior pituitary gonadotroph cells, activating phospholipase C signaling cascade, which triggers the release of stored LH and FSH into the bloodstream.
Pulsatile administration maintains receptor sensitivity and mimics physiological GnRH secretion patterns, sustaining gonadotropin output. Continuous exposure causes receptor downregulation and paradoxical suppression.
Downstream effects include stimulation of Leydig cells (testosterone production) and Sertoli cells (spermatogenesis) in males, and follicular development and ovulation in females.
What to expect
Days 1-7: Acute LH/FSH pulses occur within minutes of each injection. No subjective effects typically noticed.
Evidence
Claims we could not support
No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.
Dose/route: 100-200mcg; Subcutaneous (SubQ); 2-3x/week. No checked live PubMed abstract verified this exact displayed dose, route, and frequency for the same molecule/formulation and relevant population.
Mechanism: Binds to GnRH receptors on anterior pituitary gonadotroph cells, activating phospholipase C signaling cascade, which triggers the release of stored LH and FSH into the bloodstream.. No checked live PubMed abstract provided an exact-molecule/formulation sentence supporting this source-JSON mechanism claim.
Primary safety claim: Injection site reactions (redness, swelling, mild pain). No checked live PubMed abstract directly verified this source-JSON safety claim at the displayed formulation, route, and regimen.
Interactions & stacking
Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.
Documented together
Keep separate
Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.
Pharmacokinetics
SubQ
SubQ/IV
LH/FSH pulse
Enzymatic degradation (endopeptidases) and renal
Storage. Store refrigerated at 2-8C. Protect from light. Reconstituted solution stable for up to 14 days refrigerated.
Regulatory status
FDA-approved (Factrel, Lutrepulse) for diagnostic use and treatment of hypothalamic amenorrhea. Off-label use for fertility preservation during TRT.
Put it to work
Calculate, log & track
Open GnRH (Gonadorelin) straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open GnRH (Gonadorelin) in the app →Go deeper
The guide & community
The complete GnRH (Gonadorelin) walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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