OnePin Peptide Library · Hormonal
7-Keto DHEA
7-Keto · 7-Oxo-DHEA · 3-Acetyl-7-Oxo-DHEA
7-Keto DHEA (3-acetyl-7-oxo-DHEA, also called 7-oxo-DHEA) is a metabolite of DHEA that does NOT convert to testosterone or estrogen, distinguishing it from regular DHEA. This makes 7-Keto attractive for users wanting DHEA-like metabolic effects without the androgen/estrogen elevation concerns.
Morning preferred.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
7-Keto DHEA acts via:
Thermogenesis
Activates thermogenic enzymes (glycerol-3-phosphate dehydrogenase, malic enzyme) - increases resting metabolic rate ~3% in clinical trials.
NO Conversion to Androgens/Estrogens
7-keto position blocks reduction to testosterone or further conversion to estrogen - distinguishing from regular DHEA.
Immune Effects
Modest improvement in T-cell function in older adults.
Mood/Cognitive
Some evidence for mood support, mechanism unclear.
Cortisol Modulation
May modestly reduce cortisol response to stress.
What to expect
Days 1-14: subtle effects.
Weeks 4-12: peak benefits.
Cycle off.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Keep separate
Side effects & safety
Commonly reported
- Mild GI rare
- Mild stimulant effect
Less common & notes
- Mild thyroid acceleration in susceptible.
- Allergic reactions rare.
Pharmacokinetics
Storage. Capsule. Cool dry location.
Regulatory status
Dietary supplement (US, DSHEA).
Put it to work
Calculate, log & track
Open 7-Keto DHEA straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open 7-Keto DHEA in the app →Go deeper
The guide & community
The complete 7-Keto DHEA walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
Join the community ↗