Hormonal SERMNot FDA-approved · research compound

Enclomiphene

Encolomid · Androxal

Evidence: Studied in humans. Example dose: finalize with a provider. Not a fact-check stamp.

6.25-12.5 mg – 12.5-25mg Oral Daily

Enclomiphene is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM). While clomiphene citrate (Clomid) is a racemic mixture of enclomiphene (trans) and zuclomiphene (cis), enclomiphene is the isomer primarily responsible for the anti-estrogenic effects at the hypothalamic-pituitary level that stimulate gonadotropin release and subsequently testosterone production in men.

Quick Start

Route

Oral

Start low

12.5-25mg Oral

Frequency

daily

Timing

Can be taken with or without food

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Standard

HPTA Stimulation / TRT Alternative

6.25-12.5 mg · Oral · Daily

human clinical trial · Kaminetsky et al. 2013 (J Sex Med)

Isolated trans-isomer of clomiphene. Avoids the emotional and ocular side effects associated with the zuclomiphene isomer in standard Clomid.

6.25-12.5 mg

Daily

Conservative start

12.5-25mg · Oral · daily

conservative starter

12.5-25mg

daily

◆

How it works

Competitively blocks estrogen receptors in the hypothalamus and anterior pituitary, preventing the negative feedback of estradiol on GnRH and gonadotropin secretion. This disinhibition leads to increased pulsatile GnRH release and subsequent elevations in LH and FSH.

Elevated LH stimulates Leydig cells in the testes to produce more testosterone, while elevated FSH supports Sertoli cell function and spermatogenesis, preserving both hormonal and reproductive function.

Unlike zuclomiphene (the cis-isomer), enclomiphene has a short half-life (~10 hours) and primarily anti-estrogenic activity, avoiding the prolonged estrogenic effects and accumulation associated with racemic clomiphene.

What to expect

Early

Days 1–7

Weeks 1-2: Gonadotropins (LH, FSH) begin rising within days. Testosterone elevation begins but subjective effects are typically minimal.

Evidence

HumanPresent

AnimalPresent

In-vitroPresent

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

Enclomiphene is a non-steroidal estrogen-receptor antagonist promoting gonadotropin-dependent testosterone secretion.

Enclomiphene (Androxal), in development by Repros Therapeutics Inc, is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes.

Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men. IDrugs : the investigational drugs journal · 2009 · PMID 19204885

Evidence scope. Exact molecule; drug-development review; male secondary-hypogonadism context.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: 12.5-25 mg orally daily. Oral route and 12.5-25 mg/day appeared in separate abstracts, but no checked sentence verified the complete regimen.

Primary safety: headache, hot flashes, nausea, visual disturbance, and mood changes at this dose. No checked same-regimen abstract established the full event list; clomiphene class effects were not substituted.

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

Documented together

EpicatechinNo interaction - enclomiphene supports testosterone while epicatechin targets myostatin/follistatin independently

L-Carnitine InjectableNo pharmacological conflict - carnitine supports fat metabolism independent of SERM activity

MelatoninNo interaction - different systems (circadian vs reproductive axis)

Injectable B-ComplexB vitamins support energy metabolism - no interaction with SERM mechanism

Keep separate

Testosterone CypionateExogenous testosterone suppresses LH/FSH via negative feedback - directly counteracts enclomiphene's mechanism of stimulating endogenous production

HCGHCG provides exogenous LH-like stimulation - combining with enclomiphene creates redundant gonadotropin stimulation with unpredictable E2 elevation

Nandrolone DecanoateExogenous anabolic steroids suppress the HPG axis - negates enclomiphene's mechanism of restoring endogenous testosterone

TriptorelinGnRH agonist at continuous doses suppresses LH/FSH - directly opposes enclomiphene's mechanism

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

Pharmacokinetics

Illustrative plasma concentration · 43 h

Half-life

~10 hours

Peak · Tmax

~2-4 hours

Oral

Elimination

~2-3 days

Bioavailability

~50-60%

Oral

Duration of action

24 hours

Estrogen receptor blockade supports daily dosing; LH/FSH elevation persists throughout the day

Clearance

Hepatic (CYP-mediated metabolism); fecal and renal excretion

Storage. Store at room temperature (20-25C) in a cool, dry place. Oral compound - no reconstitution needed.

Regulatory status

Not FDA-approved. Received Complete Response Letter in 2015 for manufacturing issues. Widely available through US compounding pharmacies. Used off-label by men's health and hormone optimization clinics. Not a controlled substance in the US.

Put it to work

Calculate, log & track

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Go deeper

The guide & community

The complete Enclomiphene walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

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