OnePin Peptide Library · Hormonal
Enclomiphene
Encolomid · Androxal
Enclomiphene is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM). While clomiphene citrate (Clomid) is a racemic mixture of enclomiphene (trans) and zuclomiphene (cis), enclomiphene is the isomer primarily responsible for the anti-estrogenic effects at the hypothalamic-pituitary level that stimulate gonadotropin release and subsequently testosterone production in men.,Enclomiphene was developed by Repros Therapeutics (later Rennova Health) under the brand name Androxal specifically for the treatment of secondary hypogonadism in men - a condition where testosterone is low due to insufficient gonadotropin signaling rather than primary testicular failure. Unlike testosterone replacement therapy (TRT), enclomiphene stimulates the body's own testosterone production while preserving spermatogenesis and fertility, making it particularly attractive for younger men who wish to maintain reproductive capacity.,Despite promising Phase 3 clinical trial results showing significant testosterone elevation while maintaining sperm parameters, the FDA issued a Complete Response Letter (CRL) in 2015 citing manufacturing and formulation concerns rather than efficacy or safety issues. Enclomiphene has not received FDA approval as of 2025, though it is widely used off-label through compounding pharmacies and men's health clinics. Generic clomiphene citrate is sometimes used as an alternative, though it contains the zuclomiphene isomer which has a much longer half-life and estrogenic properties.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Competitively blocks estrogen receptors in the hypothalamus and anterior pituitary, preventing the negative feedback of estradiol on GnRH and gonadotropin secretion. This disinhibition leads to increased pulsatile GnRH release and subsequent elevations in LH and FSH.,Elevated LH stimulates Leydig cells in the testes to produce more testosterone, while elevated FSH supports Sertoli cell function and spermatogenesis, preserving both hormonal and reproductive function.,Unlike zuclomiphene (the cis-isomer), enclomiphene has a short half-life (~10 hours) and primarily anti-estrogenic activity, avoiding the prolonged estrogenic effects and accumulation associated with racemic clomiphene.
Competitively blocks estrogen receptors in the hypothalamus and anterior pituitary, preventing the negative feedback of estradiol on GnRH and gonadotropin secretion. This disinhibition leads to increased pulsatile GnRH release and subsequent elevations in LH and FSH.,Elevated LH stimulates Leydig cells in the testes to produce more testosterone, while elevated FSH supports Sertoli cell function and spermatogenesis, preserving both hormonal and reproductive function.,Unlike zuclomiphene (the cis-isomer), enclomiphene has a short half-life (~10 hours) and primarily anti-estrogenic activity, avoiding the prolonged estrogenic effects and accumulation associated with racemic clomiphene.
What to expect
Weeks 1-2: Gonadotropins (LH, FSH) begin rising within days. Testosterone elevation begins but subjective effects are typically minimal.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Store at room temperature (20-25C) in a cool, dry place. Oral compound - no reconstitution needed.
Regulatory status
Not FDA-approved. Received Complete Response Letter in 2015 for manufacturing issues. Widely available through US compounding pharmacies. Used off-label by men's health and hormone optimization clinics. Not a controlled substance in the US.
Put it to work
Calculate, log & track
Open Enclomiphene straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
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The guide & community
The complete Enclomiphene walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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