Cognitive & Mood Synthetic heptapeptideNot FDA-approved · research compound

Selank

TP-7 · Selank Acetate

Evidence: Studied in humans. Example dose: finalize with a provider. Not a fact-check stamp.

200-500 mcg daily – 200-500 mcg SubQ Daily, evening preferred for sleep support

Tuftsin analog with Pro-Gly-Pro extensionAnxiolytic peptide (non-benzodiazepine)GABA/serotonin modulatorImmunomodulatory peptide

Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), with a stabilizing Pro-Gly-Pro C-terminal extension. Developed alongside Semax at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank is approved in Russia as a prescription anxiolytic and nootropic medication. It provides anxiolytic effects through modulation of GABAergic and serotonergic neurotransmission without the sedation, cognitive impairment, or dependence associated with benzodiazepines. Selank also enhances immune function through its tuftsin-derived immunomodulatory activity. It is commonly paired with DSIP for sleep support and with Semax for balanced nootropic effects.

Quick Start

Route

SubQ injection. Also available as nasal spray (most common in Russia).

Start low

200-500 mcg SubQ

Frequency

Daily, evening preferred for sleep support

Timing

No fasting required. Evening dosing preferred for sleep benefits.

Intranasal: Any time, anxiolytic effects within minutes. SubQ: Same timing. Can be paired with Semax. No fasting required.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Conservative start

200-500 mcg daily · SubQ injection. Also available as nasal spray (most common in Russia). · Daily, evening preferred for sleep support

conservative starter

200-500 mcg daily

Daily, evening preferred for sleep support

Standard

Anxiolytic Clarity

200-500 mcg · SubQ · Daily

human study · Zozulya et al. 2001 (Bull Exp Biol Med)

Intranasal is also highly common. Best for individuals with anxiety who need to remain cognitively sharp.

200-500 mcg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Vials in this mix

Syringe size

Target dose

050100u

Draw to

— units

◆

I will split this dose across more than one syringe

◆

How it works

Selank modulates GABA-A receptor sensitivity, enhancing inhibitory neurotransmission without directly binding the benzodiazepine site, which prevents sedation and dependence. It also influences serotonin (5-HT) metabolism by affecting tryptophan hydroxylase activity and serotonin transporter dynamics, contributing to mood stabilization and anxiety reduction. The tuftsin core (Thr-Lys-Pro-Arg) provides immunomodulatory activity by enhancing phagocytic activity of macrophages and neutrophils, natural killer cell function, and IL-6 expression. The Pro-Gly-Pro extension protects against aminopeptidase degradation, extending effective half-life. Gene expression studies show Selank modulates approximately 80 genes related to GABAergic signaling, serotonergic pathways, and immune function.

What to expect

Early

Days 1–7

Days 1-3: Many users report noticeable anxiety reduction within the first few days. Sleep quality improvements if dosed in the evening. No sedation or cognitive dulling.

Mid

Weeks 2–4

Weeks 1-4: Consistent anxiolytic effects. Stress resilience improves. Sleep quality stabilizes. Immune function benefits begin to accumulate. Best results when paired with Semax for cognitive balance.

Later

Weeks 4–12

Weeks 4-8: Sustained mood and anxiety benefits. Immune modulation fully established. No tolerance or dependence develops. Cycling is recommended to maintain receptor sensitivity.

Evidence

HumanPresent

AnimalStrong

In-vitroPresent

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.

The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in pharmacology · 2016 · PMID 26924987

Evidence scope. Gene-expression study; route/model does not validate the card's subcutaneous or nasal dose.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: 200-500 mcg daily via SubQ injection. Also available as nasal spray (most common in Russia)., Daily, evening preferred for sleep support. No checked live PubMed abstract supported this complete molecule/formulation/route/dose/frequency combination.

Primary safety claim: Generally very well tolerated. No checked live abstract directly established this as the primary concern for the card's exact formulation and regimen.

The honest take

◆

Non-benzodiazepine anxiolytic

Strongest claim. Approved in Russia for anxiety. Human studies show anxiolytic efficacy comparable to medazepam without sedation, cognitive impairment, or dependence risk.

Immune enhancement

Tuftsin-derived immunomodulatory activity is well-documented. Enhanced phagocytic activity and NK cell function. Dual anxiolytic + immune support is unique among peptides.

No tolerance or dependence

Supported

Confirmed by Russian clinical data. Selank does not bind the benzodiazepine site and does not produce tolerance, dependence, or withdrawal. Major safety advantage over benzodiazepines.

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

Documented together

BPC-157Non-overlapping (anxiolytic vs tissue repair)

TB-500Non-overlapping mechanisms

GHK-CuNon-overlapping mechanisms

GHKNon-overlapping mechanisms

Keep separate

CJC-1295 with DACDAC maleimide reactivity concern.

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

Side effects & safety

Commonly reported

Generally very well tolerated
Mild injection site irritation
Occasional mild fatigue (usually first few days)
Rare nasal irritation if using intranasal route

Less common & notes

Selank has an excellent safety profile in Russian clinical use.
No dependence, tolerance, or withdrawal reported.
No cognitive impairment.
Rarely, mild headache.
Individuals on SSRIs or other serotonergic medications should use caution as Selank modulates serotonin metabolism.
Consult physician if on psychiatric medications.

Pharmacokinetics

Illustrative plasma concentration · 2.8 h

Half-life

0.5h

Peak · Tmax

0.75h

Elimination

2.5h

Bioavailability

~100%

SubQ, ~92% Nasal

Duration of action

6-12 hours

Anxiolytic and GABA/serotonin modulation effects outlast plasma presence

Clearance

Enzymatic degradation (aminopeptidases); Pro-Gly-Pro extension slows degradation

Storage. Store unreconstituted vials frozen (-20C) or refrigerated (2-8C). After reconstitution with BAC water, refrigerate at 2-8C. Stable for 28 days. Pro-Gly-Pro modification enhances enzymatic stability. Protect from light.

Regulatory status

Approved as a prescription medication in Russia for anxiety and cognitive disorders. Not FDA-approved in the United States. Available as a research peptide. WADA status: Not specifically listed. Not a controlled substance.

Put it to work

Calculate, log & track

Open Selank straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Selank in the app →

Go deeper

The guide & community

The complete Selank walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

Open in app Community