OnePin Peptide Library · Immune
Thymulin
Thymulin Zinc
Thymulin, also known as Facteur Thymique Serique (FTS) or serum thymic factor, is a nonapeptide hormone (Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn) produced exclusively by thymic epithelial cells. It is unique among thymic hormones in that it requires zinc to be biologically active - the zinc-thymulin complex (ZnFTS) is the functional form that binds to high-affinity receptors on T-cells.,Thymulin was first isolated and characterized by Jean-Francois Bach and colleagues in the 1970s at the Hopital Necker in Paris. It plays a critical role in T-cell differentiation within the thymus, promoting the maturation of precursor cells into functional T-lymphocytes. Serum thymulin levels decline dramatically with age, paralleling thymic involution, making it a biomarker of thymic function and immune aging.,Research into thymulin has focused on its role in immunosenescence (age-related immune decline) and its potential as a therapeutic agent. Studies have explored thymulin replacement in aged animals, showing restoration of various immune parameters. Synthetic thymulin and zinc-thymulin analogs are available as research compounds but are not approved for clinical use by any major regulatory agency.
SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Binds to specific high-affinity receptors on immature T-cell precursors in a zinc-dependent manner, triggering intracellular signaling cascades that promote T-cell differentiation, expression of T-cell surface markers (CD2, CD3, CD4, CD8), and functional maturation.,Modulates cytokine production by mature T-cells, promoting IL-2 secretion and shifting the Th1/Th2 balance. Also enhances NK cell cytotoxicity and modulates B-cell antibody production indirectly through T-helper cell regulation.,Exerts anti-inflammatory effects in the central nervous system by reducing microglial activation and pro-inflammatory cytokine production. Has been shown to reduce neuroinflammation in animal models of pain and neurodegenerative disease.
Binds to specific high-affinity receptors on immature T-cell precursors in a zinc-dependent manner, triggering intracellular signaling cascades that promote T-cell differentiation, expression of T-cell surface markers (CD2, CD3, CD4, CD8), and functional maturation.,Modulates cytokine production by mature T-cells, promoting IL-2 secretion and shifting the Th1/Th2 balance. Also enhances NK cell cytotoxicity and modulates B-cell antibody production indirectly through T-helper cell regulation.,Exerts anti-inflammatory effects in the central nervous system by reducing microglial activation and pro-inflammatory cytokine production. Has been shown to reduce neuroinflammation in animal models of pain and neurodegenerative disease.
What to expect
Days 1-7: No established human timeline. Animal data suggests initial immune cell priming during the first week. Zinc status should be optimized concurrently.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Store refrigerated at 2-8C. Protect from light. Extremely sensitive to degradation. Reconstituted solutions should be used promptly.
Regulatory status
Research compound only. Not approved for clinical use by FDA, EMA, or any major regulatory agency. No IND applications on record.
Put it to work
Calculate, log & track
Open Thymulin straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Thymulin in the app →Go deeper
The guide & community
The complete Thymulin walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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