OnePin Peptide Library · Immune
Thymopentin
Thymopoietin Fragment · TP-5
Thymopentin (TP-5) is a synthetic pentapeptide corresponding to amino acids 32-36 (Arg-Lys-Asp-Val-Tyr) of the natural thymic hormone thymopoietin. Thymopoietin is a 49-amino acid polypeptide produced by thymic epithelial cells that plays a critical role in T-cell differentiation and immune regulation. Thymopentin retains the full biological activity of the parent hormone in a much smaller, more stable molecule.,Thymopentin works primarily by promoting the differentiation of precursor T-cells into mature, functional T-lymphocytes. It enhances both the number and function of T-cells, modulates cytokine production, and can restore depressed immune function. It has been studied extensively since the 1980s for a range of immunodeficiency conditions.,Thymopentin has been approved in several countries including China and Italy for clinical use in immunodeficiency states. In China, it is widely used as an adjunct therapy for hepatitis B, certain cancers, and recurrent infections. It has not been FDA-approved in the United States but was the subject of multiple clinical trials in the 1980s-1990s, including studies in HIV/AIDS and rheumatoid arthritis.
SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Induces differentiation of immature T-cell precursors (pro-thymocytes) into mature CD4+ and CD8+ T-lymphocytes by mimicking the active site of thymopoietin, promoting expression of T-cell surface markers.,Modulates the balance between T-helper (Th1/Th2) subsets and enhances natural killer (NK) cell activity, improving both cellular immunity and immunosurveillance.,Stimulates production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) while suppressing excessive inflammatory cytokine production, creating a balanced immune response.
Induces differentiation of immature T-cell precursors (pro-thymocytes) into mature CD4+ and CD8+ T-lymphocytes by mimicking the active site of thymopoietin, promoting expression of T-cell surface markers.,Modulates the balance between T-helper (Th1/Th2) subsets and enhances natural killer (NK) cell activity, improving both cellular immunity and immunosurveillance.,Stimulates production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) while suppressing excessive inflammatory cytokine production, creating a balanced immune response.
What to expect
Days 1-14: Immune cell differentiation processes begin. No clinically noticeable effects in most patients.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Store refrigerated at 2-8C. Reconstituted solution should be used within 14 days.
Regulatory status
Approved pharmaceutical in China and Italy for immunodeficiency states. Not FDA-approved in the US. Investigated in US clinical trials in the 1980s-1990s.
Put it to work
Calculate, log & track
Open Thymopentin straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Thymopentin in the app →Go deeper
The guide & community
The complete Thymopentin walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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