Immune Khavinson bioregulatorNot FDA-approved · research compound

Thymalin

Thymalin (Khavinson Polypeptide Complex)

Evidence: Studied in humans. Example dose: finalize with a provider. Not a fact-check stamp.

1-5 mg daily SubQ 5-10 day pulsed course. Reconstitute with SALINE.

10 mg IM Daily

Thymus gland regulatorImmune system modulatorGene expression modulator

Thymalin is a Khavinson bioregulator peptide complex originally extracted from calf thymus gland, targeting thymic tissue gene expression and immune system regulation. It supports T-cell maturation, thymic function restoration, and immune competence. Thymalin was one of the first bioregulators developed by Khavinson's group and has the most extensive Russian clinical data of any bioregulator, including a landmark 15-year follow-up study showing reduced mortality in elderly patients.

Quick Start

Route

SubQ or IM injection

Start low

1-5 mg SubQ

Frequency

5-10 day pulsed course. Reconstitute with SALINE.

Timing

No fasting required

Starting dose. 1-5 mg — Daily

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Conservative start

1-5 mg daily · SubQ or IM injection · 5-10 day pulsed course. Reconstitute with SALINE.

conservative starter

1-5 mg daily

5-10 day pulsed course. Reconstitute with SALINE.

Expert

Deep Immune Reconstitution

10 mg · IM · Daily

human clinical trial · Khavinson & Morozov 2003 (Neuroendocrinol Lett, Vol. 24, Nos. 3/4)

Must be administered IM. Highly synergistic when run concurrently with Epithalon for a 10-day longevity reset.

10 mg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Vials in this mix

Syringe size

Target dose

050100u

Draw to

— units

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I will split this dose across more than one syringe

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How it works

Thymalin modulates gene expression in thymic epithelial cells and thymocytes, supporting the thymic microenvironment necessary for T-cell development and maturation. It upregulates genes involved in thymopoiesis, T-cell receptor rearrangement, and immune cell differentiation. The thymus involutes (shrinks) significantly with age, and Thymalin partially restores thymic gene expression patterns toward a more youthful state.

What to expect

Early

Days 1–7

Days 1-10: Gene changes initiated.

Mid

Weeks 2–4

Weeks 2-8: Thymic gene programs established.

Later

Weeks 4–12

Months-years: Sustained immune optimization. Khavinson's data showed benefits over 15-year follow-up.

Evidence

HumanStrong

AnimalPresent

In-vitroPresent

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

Exact-molecule evidence boundary: the live abstract reports the quoted finding for Thymalin; no broader inference is made.

Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences and the Institute of Gerontology of the Ukrainian Academy of Medical Sciences (Kiev) clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.

Peptides of pineal gland and thymus prolong human life. Neuro endocrinology letters · 2003 · PMID 14523363

Evidence scope. Exact molecule wording appears in the quoted live sentence. Only the population/model, formulation, route, and outcome expressly stated there are supported.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: 1-5 mg daily; SubQ or IM injection; 5-10 day pulsed course. Reconstitute with SALINE.. No selected live abstract sentence verified this complete regimen.

Mechanism as written in source JSON. No selected live abstract sentence verified the complete mechanism at the card formulation/route and relevant population/model.

Primary safety claim as written in source JSON. No selected live abstract sentence verified the complete safety claim for this exact formulation and route.

The honest take

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Longevity / mortality reduction

Khavinson's 15-year study showed reduced mortality with Thymalin + Epithalon. Most compelling longevity data for any bioregulator. Methodology debated by Western standards.

Thymic rejuvenation

Partly true

Gene expression data supports partial restoration of thymic function in aged tissue. Consistent with Khavinson's bioregulatory theory.

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

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Pin alone. Thymalin must not share a syringe with anything else, whatever the pharmacology says. PIN ALONE. Khavinson bioregulator.

Documented together

TA-1Both target thymus. Thymalin bioregulates thymic gene expression, TA-1 directly modulates immune effector cells. Complementary. Run in sequence.

EpithalonKhavinson's original longevity protocol combines Thymalin (immune) with Epithalon (telomerase). Run in sequence.

VladonixBoth target thymus through different bioregulatory mechanisms. Can alternate courses.

Keep separate

GHK-CuCopper degrades bioregulators.

Immunosuppressive drugsThymalin upregulates immune function. May conflict with immunosuppression.

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

Side effects & safety

Commonly reported

Very well tolerated
Mild injection site irritation
Rare transient flu-like symptoms (immune activation)

Less common & notes

Autoimmune caution: immune upregulation could theoretically exacerbate autoimmune conditions.
Consult physician.

Pharmacokinetics

Illustrative plasma concentration · 2.3 h

Half-life

0.5h

Peak · Tmax

0.25h

Elimination

2.5h

Bioavailability

~100%

SubQ

Duration of action

Months to years (epigenetic immune gene expression changes persist; Khavinson 15-year data supports lasting effects)

Clearance

Enzymatic degradation (aminopeptidases and endopeptidases)

Storage. Standard BAC water 2-8C. 21-28 days.

Regulatory status

Not FDA-approved. Used extensively in Russian clinical medicine. Research peptide in the West.

Put it to work

Calculate, log & track

Open Thymalin straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Thymalin in the app →

Go deeper

The guide & community

The complete Thymalin walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

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