library.onepin.app/thymalin Peptide Education Library

Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Immune

Immune Khavinson bioregulator Not FDA-approved · investigational

Thymalin

Thymalin (Khavinson Polypeptide Complex)

Khavinson bioregulatorThymus gland regulatorImmune system modulatorGene expression modulator

Thymalin is a Khavinson bioregulator peptide complex originally extracted from calf thymus gland, targeting thymic tissue gene expression and immune system regulation. It supports T-cell maturation, thymic function restoration, and immune competence. Thymalin was one of the first bioregulators developed by Khavinson's group and has the most extensive Russian clinical data of any bioregulator, including a landmark 15-year follow-up study showing reduced mortality in elderly patients.

Quick Start

Route

SubQ or IM injection

Start low

10 mg daily

Frequency

Daily for 10-20 day course

Timing

No fasting required

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Quick Start

Conservative start

10 mg daily · SubQ or IM injection · Daily for 10-20 day course

Lowest starting point. Hold about a week to assess tolerance before stepping up.

10 mg daily

Daily for 10-20 day course

Expert

Deep Immune Reconstitution

10 mg · IM · Daily

human clinical trial · Khavinson & Morozov 2003 (Neuroendocrinol Lett, Vol. 24, Nos. 3/4)

10 mg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Target dose

050100u

Draw to

— units

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How it works

Thymalin modulates gene expression in thymic epithelial cells and thymocytes, supporting the thymic microenvironment necessary for T-cell development and maturation. It upregulates genes involved in thymopoiesis, T-cell receptor rearrangement, and immune cell differentiation. The thymus involutes (shrinks) significantly with age, and Thymalin partially restores thymic gene expression patterns toward a more youthful state.

What to expect

Early

Days 1–7

Days 1-10: Gene changes initiated.

Mid

Weeks 2–4

Weeks 2-8: Thymic gene programs established.

Later

Weeks 4–12

Months-years: Sustained immune optimization. Khavinson's data showed benefits over 15-year follow-up.

Evidence

HumanStrong

AnimalPresent

In-vitroPresent

2003Peptides of pineal gland and thymus prolong human life · Khavinson VK, Morozov VG, Neuro Endocrinology Letters ↗peer reviewed

2003Geroprotective effect of thymalin and epithalamin · Anisimov VN, Khavinson VK, Morozov VG, Advances in Gerontology ↗peer reviewed

2021The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity · Kuznik BI et al, International Journal of Molecular Sciences ↗review

2013Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results · Khavinson VK et al, Advances in Gerontology ↗review

The honest take

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Longevity / mortality reduction

Khavinson's 15-year study showed reduced mortality with Thymalin + Epithalon. Most compelling longevity data for any bioregulator. Methodology debated by Western standards.

Thymic rejuvenation

Partly true

Gene expression data supports partial restoration of thymic function in aged tissue. Consistent with Khavinson's bioregulatory theory.

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Safe & synergistic

TA-1Both target thymus. Thymalin bioregulates thymic gene expression, TA-1 directly modulates immune effector cells. Complementary. Run in sequence.

EpithalonKhavinson's original longevity protocol combines Thymalin (immune) with Epithalon (telomerase). Run in sequence.

VladonixBoth target thymus through different bioregulatory mechanisms. Can alternate courses.

Keep separate

ALL (syringe)PIN ALONE. Khavinson bioregulator.

GHK-CuCopper degrades bioregulators.

Immunosuppressive drugsThymalin upregulates immune function. May conflict with immunosuppression.

Side effects & safety

Commonly reported

Very well tolerated
Mild injection site irritation
Rare transient flu-like symptoms (immune activation)

Less common & notes

Autoimmune caution: immune upregulation could theoretically exacerbate autoimmune conditions.
Consult physician.

Pharmacokinetics

Illustrative plasma concentration · 24 h

Half-life

0.5h

Peak · Tmax

0.25h

Elimination

2.5h

Activity

Months to years (epigenetic immune gene expression changes persist; Khavinson 15-year data supports lasting effects)

Storage. Standard BAC water 2-8C. 21-28 days.

Regulatory status

Not FDA-approved. Used extensively in Russian clinical medicine. Research peptide in the West.

Put it to work

Calculate, log & track

Open Thymalin straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Thymalin in the app →

Go deeper

The guide & community

The complete Thymalin walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

Open in app Community