OnePin Peptide Library · Bioregulators
Thymogen
Thymogen (Khavinson) · Glutamyl-Tryptophan
Thymogen (glutamyl-tryptophan, or EW dipeptide) is a synthetic bioregulatory peptide developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in Russia. It is a short-chain dipeptide consisting of L-glutamic acid and L-tryptophan, designed to mimic the immunomodulatory activity of thymic peptides.,Thymogen was developed as part of Khavinson's bioregulator research program, which posits that short peptides can regulate gene expression in specific tissues. Thymogen is intended to target the thymus gland and immune system, promoting T-cell maturation and restoring immune function that declines with age (immunosenescence). It has been registered as a pharmaceutical product in Russia for immune support.,As a bioregulatory peptide, Thymogen is used in cycles following the Khavinson protocol. It is approved in Russia as a nasal spray and injectable for immune deficiency states, but it has not undergone FDA review and is not approved for use in the United States or European Union. Most published research comes from Russian clinical studies.
SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Proposed to act as a gene-regulatory peptide that interacts with DNA sequences in immune cells, modulating expression of genes involved in T-cell differentiation, maturation, and cytokine production.,May enhance thymic output of naive T-cells and restore the balance between T-helper and T-suppressor cell populations, improving overall immune surveillance.,The tryptophan component may influence serotonin and melatonin pathways, though the primary mechanism is believed to be direct peptide-DNA interaction at the epigenetic level according to Khavinson's bioregulation theory.
Proposed to act as a gene-regulatory peptide that interacts with DNA sequences in immune cells, modulating expression of genes involved in T-cell differentiation, maturation, and cytokine production.,May enhance thymic output of naive T-cells and restore the balance between T-helper and T-suppressor cell populations, improving overall immune surveillance.,The tryptophan component may influence serotonin and melatonin pathways, though the primary mechanism is believed to be direct peptide-DNA interaction at the epigenetic level according to Khavinson's bioregulation theory.
What to expect
Days 1-7: Subtle or no noticeable effects. The peptide is thought to initiate gene-regulatory changes in immune cells during this period.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Keep separate
Pharmacokinetics
Storage. Store refrigerated at 2-8C. Reconstituted solution should be used within 14-28 days.
Regulatory status
Approved pharmaceutical in Russia for immune modulation. Not FDA-approved. Classified as a research compound in the US and EU.
Put it to work
Calculate, log & track
Open Thymogen straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Thymogen in the app →Go deeper
The guide & community
The complete Thymogen walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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