OnePin Peptide Library · Bioregulators
Pinealon
Pinealon (Khavinson)
Pinealon (Glu-Asp-Arg) is a Khavinson bioregulator tripeptide that targets the pineal gland and central nervous system. It was developed by Professor Vladimir Khavinson's research group at the St. Petersburg Institute of Bioregulation and Gerontology. Pinealon regulates gene expression in pineal and CNS tissue, supporting melatonin production, circadian rhythm maintenance, and neuroprotective pathways. Like all Khavinson bioregulators, it works at very low concentrations through direct DNA interaction rather than classical receptor binding, and is administered in short intensive courses (10-20 days) followed by extended rest periods of several months.
Evening/bedtime preferred (pineal bioregulator). 10-20 day courses.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Pinealon interacts with DNA in pineal gland and CNS cells at the level of histone modification and transcription factor accessibility, modulating expression of genes involved in melatonin synthesis (AANAT, ASMT), circadian clock regulation, and neuroprotective pathways. As a bioregulator, it does not activate traditional cell surface receptors but instead penetrates cells and directly influences gene transcription. The tripeptide structure allows cell penetration and nuclear localization. Effects persist beyond the dosing period because gene expression changes are sustained through epigenetic mechanisms.
Pinealon interacts with DNA in pineal gland and CNS cells at the level of histone modification and transcription factor accessibility, modulating expression of genes involved in melatonin synthesis (AANAT, ASMT), circadian clock regulation, and neuroprotective pathways. As a bioregulator, it does not activate traditional cell surface receptors but instead penetrates cells and directly influences gene transcription. The tripeptide structure allows cell penetration and nuclear localization. Effects persist beyond the dosing period because gene expression changes are sustained through epigenetic mechanisms.
What to expect
Days 1-10 (during course): Sleep improvements may be noticeable. Gene expression changes initiated.
Weeks 2-8 (after course): Gene expression changes continue to manifest. Sleep benefits persist.
Months: Sustained pineal function improvement. Run next course in 4-6 months.
Evidence
The honest take
Pineal gland restoration
Russian clinical data supports improved melatonin production and circadian rhythm in elderly. Mechanism (gene expression modulation) is consistent with Khavinson bioregulatory theory.
Animal and in vitro data support CNS protective effects. Mechanism involves upregulation of neuroprotective gene programs.
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Side effects & safety
Commonly reported
- Very well tolerated
- Mild injection site irritation
Less common & notes
- Pinealon is a small tripeptide with excellent safety profile.
- No significant adverse events in published literature.
- Short course duration limits exposure.
Pharmacokinetics
Storage. Standard BAC water 2-8C. 21-28 days stability. Short course means shelf life rarely an issue.
Regulatory status
Not FDA-approved. Available as research peptide. Used in Russian clinical practice. No WADA prohibition.
Put it to work
Calculate, log & track
Open Pinealon straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Pinealon in the app →Go deeper
The guide & community
The complete Pinealon walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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