library.onepin.app/cardiogen Peptide Education Library

Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Bioregulators

Bioregulators Khavinson bioregulator tetrapeptide Not FDA-approved · investigational

Cardiogen

Cardiogen (Khavinson)

Khavinson bioregulator tetrapeptideCardiac tissue regulatorGene expression modulator

Cardiogen (Ala-Glu-Asp-Arg) is a Khavinson bioregulator tetrapeptide targeting cardiac tissue gene expression. It supports cardiomyocyte function, cardiac extracellular matrix maintenance, and cardiovascular protective pathways. Developed for age-related cardiac decline and cardiac tissue support.

Quick Start

Route

SubQ injection

Start low

5 mg daily

Frequency

Daily for 10-20 day course

Timing

No fasting required

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Quick Start

Conservative start

5 mg daily · SubQ injection · Daily for 10-20 day course

Lowest starting point. Hold about a week to assess tolerance before stepping up.

5 mg daily

Daily for 10-20 day course

Standard

Cardiovascular Bioregulation

10-20 mg · Oral · Daily

anecdotal · community

10-20 mg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Target dose

050100u

Draw to

— units

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How it works

Cardiogen penetrates cardiomyocytes and interacts with DNA to modulate expression of genes involved in cardiac contractility, extracellular matrix maintenance, antioxidant defense, and cellular stress resistance in heart tissue. Works through epigenetic mechanisms at very low concentrations.

What to expect

Early

Days 1–7

Days 1-10: Gene expression changes initiated.

Mid

Weeks 2–4

Weeks 2-8: Cardiac gene programs established.

Later

Weeks 4–12

Months: Sustained cardiac tissue support.

Evidence

HumanPresent

AnimalPresent

In-vitroPresent

2013Peptide bioregulators: the new class of geroprotectors. Communication 1. Results of experimental studies · Khavinson VK, Kuznik BI, Advances in Gerontology ↗review

2013Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results · Khavinson VK, Kuznik BI, Advances in Gerontology ↗review

2022Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line · Lin'kova NS et al, International Journal of Molecular Sciences ↗peer reviewed

2000Application of peptide bioregulators in gerontology: results and perspectives · Khavinson VK, Advances in Gerontology ↗review

The honest take

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Cardiac tissue support

Russian clinical data supports improved cardiac markers in elderly. Bioregulatory mechanism targets cardiac-specific gene expression.

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Safe & synergistic

SS-31Cardiogen targets cardiac gene expression, SS-31 targets cardiac mitochondria. Complementary cardiac support. Pin separately.

VesiluteCardiogen cardiac + Vesilute vascular. Complementary cardiovascular support. Run in sequence.

Keep separate

ALL (syringe)PIN ALONE. Khavinson bioregulator.

GHK-CuCopper degrades bioregulator peptides.

Side effects & safety

Commonly reported

Very well tolerated
Mild injection site irritation

Less common & notes

Monitor cardiovascular parameters if on cardiac medications.
Excellent safety profile.

Pharmacokinetics

Illustrative plasma concentration · 24 h

Half-life

0.5h

Peak · Tmax

0.08h

Elimination

2.5h

Activity

Weeks to months (cardiac gene expression changes persist long after peptide clearance)

Storage. Standard BAC water 2-8C. 21-28 days.

Regulatory status

Not FDA-approved. Research peptide. Used in Russian clinical practice.

Put it to work

Calculate, log & track

Open Cardiogen straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Cardiogen in the app →

Go deeper

The guide & community

The complete Cardiogen walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

Open in app Community