OnePin Peptide Library · Cognitive & Mood
Hypness Blend
Hypness Stack · Hypness
The Hypness Blend is a four-peptide sleep and GH recovery combination containing DSIP 5mg, Selank 5mg, CJC-1295 no DAC 6mg, and Ipamorelin 12mg for a total of 28mg per vial in 5mL. This blend targets two complementary nighttime systems simultaneously: sleep architecture optimization through DSIP and Selank, and growth hormone release through the CJC/Ipamorelin GHRH+GHRP axis. The result is a single bedtime injection that promotes deep restorative sleep while maximizing the nocturnal GH pulse that naturally peaks during slow-wave sleep.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
The Hypness Blend works through four complementary mechanisms timed for bedtime administration:
The Hypness Blend works through four complementary mechanisms timed for bedtime administration:
DSIP Component (5mg): Enhances GABAergic inhibitory tone to promote sleep onset and maintenance, normalizes cortisol circadian rhythm (reducing evening cortisol that interferes with sleep), and modulates serotonin metabolism affecting sleep-wake transitions. DSIP forms complexes with carrier proteins that serve as slow-release reservoirs, extending its effective window through the night despite a short plasma half-life.
Selank Component (5mg): Modulates GABA-A receptor sensitivity without directly binding the benzodiazepine site, providing anxiolytic calming without sedation or dependence. Also influences serotonin metabolism to stabilize mood and reduce pre-sleep anxiety. The tuftsin-derived immunomodulatory activity provides additional immune support during the sleep recovery window.
CJC-1295 no DAC Component (6mg): Binds GHRH receptors on pituitary somatotrophs, activating cAMP/PKA signaling to prime GH release. The ~30 minute half-life produces an acute GH pulse that aligns with the natural nocturnal GH surge during slow-wave sleep.
Ipamorelin Component (12mg): Selectively activates ghrelin receptors (GHS-R1a) on the pituitary through a separate intracellular pathway from CJC. The dual GHRH + GHRP stimulation produces synergistic GH pulses 3-5x greater than either alone. Ipamorelin does not significantly affect cortisol, prolactin, or appetite at standard doses.
Synergy: DSIP and Selank deepen sleep, creating optimal conditions for GH release. CJC and Ipamorelin amplify the nocturnal GH pulse that naturally peaks during the deep sleep promoted by DSIP. The result is a reinforcing cycle where deeper sleep enables greater GH output, and elevated GH further supports restorative sleep processes.
What to expect
Days 1-7: Selank anxiolytic effects often noticeable from the first dose, with reduced pre-sleep anxiety and faster sleep onset. DSIP delta wave promotion begins shifting sleep architecture toward deeper stages within 2-3 nights. Some users report more vivid dreams. CJC/Ipa GH pulses begin immediately but body composition changes are not yet visible. Mild injection site redness may occur.
Weeks 2-4: Sleep quality improvements become consistent and pronounced. Delta wave sleep duration increases measurably. Morning recovery feeling markedly improved. GH-mediated benefits begin emerging: improved skin quality, better workout recovery, subtle body composition shifts. Cortisol rhythm normalization from DSIP contributes to improved daytime energy.
Weeks 4-12: Full cumulative benefits realized. Sleep architecture remodeled with sustained deep sleep improvement. Body composition changes visible from consistent nocturnal GH elevation. Recovery capacity noticeably enhanced. Consider cycling off after 8-12 weeks with a 4-week break to maintain receptor sensitivity for both the GH axis and sleep peptides.
Evidence
The honest take
Single bedtime injection optimizes both sleep architecture and nocturnal GH release
PlausibleMechanistically plausible. DSIP promotes delta wave sleep, and GH is naturally released during slow-wave sleep. CJC/Ipa stimulates GH release. The synergy between deeper sleep and pharmacological GH stimulation is a reasonable hypothesis but has not been directly measured with this combination.
Partially supported. Human studies from the 1980s-1990s showed some delta wave promotion, but results were inconsistent across studies. The evidence base is limited by small sample sizes and dated methodology. Animal data is more consistent.
Supported by Russian clinical trials comparing Selank to medazepam. Selank showed comparable anxiolytic effects without the sedation, cognitive impairment, or dependence risk. These trials have limited Western peer review but represent meaningful clinical data.
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Side effects & safety
Commonly reported
- Vivid dreams or increased dream recall (DSIP effect)
- Mild injection site redness or warmth
- Occasional lightheadedness immediately post-injection
- Slight numbness or tingling in extremities from GH pulse (water retention)
- Mild morning grogginess during first few days of DSIP adjustment
Less common & notes
- Rarely reported: transient nausea, headache, temporary water retention from GH elevation.
- Ipamorelin is the cleanest GHRP with minimal cortisol or prolactin stimulation.
- DSIP and Selank have favorable safety profiles.
- Long-term human safety data for this specific combination does not exist.
Pharmacokinetics
Storage. Reconstitute with bacteriostatic water. Store refrigerated at 2-8 degrees C. Shelf life approximately 28 days after reconstitution. Do not freeze after reconstitution. Protect from light. Discard if cloudy or particulate matter visible. The multi-component nature of this blend means stability is limited by the least stable component.
Regulatory status
Not FDA-approved. Available through compounding pharmacies and research suppliers. Selank and Semax are approved medications in Russia. DSIP, CJC-1295 no DAC, and Ipamorelin are classified as research peptides. Ipamorelin has undergone Phase 1-2 human trials. All use of this blend is experimental and off-label.
Put it to work
Calculate, log & track
Open Hypness Blend straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
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The guide & community
The complete Hypness Blend walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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