library.onepin.app/saw-palmetto Peptide Education Library
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OnePin Peptide Library · Hormonal

Hormonal Serenoa repens (North American Palm Berry)

Saw Palmetto

Serenoa repens

Serenoa repens (North American Palm Berry)5-α-Reductase Inhibitor (mild)BPH / Hair Loss AdjunctDietary Supplement

Saw Palmetto (Serenoa repens) is the berry of a North American palm tree, traditionally used for prostate health and male hormonal balance. Active compounds include free fatty acids and phytosterols, particularly β-sitosterol. The most-studied form is a CO2-extracted lipidosterolic extract standardized to 85-95% fatty acids and sterols.

Quick Start
Route
Oral capsule or softgel
Start low
320mg standardized lipidosterolic extract
Frequency
1-2x daily
Timing
With food

With meals.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
320mg standardized lipidosterolic extract · Oral capsule or softgel · 1-2x daily
Lowest starting point. Hold about a week to assess tolerance before stepping up.
320mg standardized lipidosterolic extract
1-2x daily
Standard
Prostate Support
320 mg · Oral · Daily
human clinical trial · Marks et al. 2000 (J Urol)
320 mg
Daily
◆
01

How it works

Saw Palmetto's lipidosterolic extract has multiple effects:

Mild 5-α-Reductase Inhibition

Reduces conversion of testosterone to DHT - mechanism shared with finasteride/dutasteride but much weaker. Basis of BPH and hair loss applications.

Anti-Androgenic Receptor Effects

Some evidence for direct androgen receptor antagonism beyond 5-α-reductase.

Anti-Inflammatory

COX and 5-LOX modulation - reduces prostatic inflammation.

β-Sitosterol Component

Plant sterol with separate evidence for BPH symptom relief.

Distinct from Finasteride

Much weaker 5-α-reductase inhibition; correspondingly weaker effects (and side effects) than the pharmaceutical.

02

What to expect

Early
Days 1–7

Days 1-28: minimal subjective change.

Mid
Weeks 2–4

Weeks 8-12: peak BPH effects in responders.

Later
Weeks 4–12

Long-term continuous use OK.

03

Evidence

HumanModerate
AnimalPresent
In-vitroPresent
1998Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review · Wilt TJ et al, JAMA ↗review
2006Saw palmetto for benign prostatic hyperplasia (STEP trial) · Bent S et al, New England Journal of Medicine ↗peer reviewed
1996Comparative effects of finasteride and Permixon in benign prostatic hyperplasia · Carraro JC et al, Prostate ↗peer reviewed
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

05

Side effects & safety

Commonly reported

  • Mild GI
  • Mild headache

Less common & notes

  • Sexual side effects rare (much less common than finasteride).
  • Allergic reactions rare.
  • Long-term safety good.
06

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
Variable per component
Peak · Tmax
1-3 hours
Elimination
Hours plasma; cumulative prostate effects over weeks
Activity
Daily dosing for sustained effects

Storage. Softgel/capsule. Cool dry location.

07

Regulatory status

Dietary supplement (US, DSHEA). Permixon is pharmaceutical in EU.

Put it to work

Calculate, log & track

Open Saw Palmetto straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Saw Palmetto in the app →

Go deeper

The guide & community

The complete Saw Palmetto walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
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