Cialis
Tadalafil (brand names Cialis, Adcirca) is a long-acting, selective phosphodiesterase-5 (PDE5) inhibitor approved for erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). Compared to other PDE5 inhibitors (sildenafil/Viagra, vardenafil/Levitra), tadalafil's distinguishing feature is its dramatically longer half-life - ~17.5 hours vs 3-5 hours for sildenafil. This makes it suitable for daily low-dose use (2.5-5mg daily) rather than only on-demand higher dosing.
Starting dose. 5mg — Daily (Cialis daily) OR 10mg on-demand
Daily dose: take same time each day with or without food. On-demand: take 30 min - 2 hours before sexual activity (effect can last 24-36 hours). Avoid taking with high-fat meals on first doses (slightly delays onset, minimally affects efficacy).
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
Tadalafil selectively inhibits PDE5 (phosphodiesterase type 5), the enzyme that breaks down cyclic guanosine monophosphate (cGMP). Inhibiting PDE5 increases cGMP levels in tissues with high PDE5 expression - primarily corpus cavernosum (penile erectile tissue), prostate/bladder smooth muscle, and pulmonary vasculature.
Increased cGMP causes smooth muscle relaxation via protein kinase G activation. In penile tissue, this allows arterial inflow and venous occlusion necessary for erection (in response to sexual stimulation - tadalafil doesn't cause spontaneous erections without arousal).
In prostate and bladder smooth muscle, cGMP increase relaxes lower urinary tract tissue, improving urinary flow in BPH.
In pulmonary vasculature, cGMP-mediated vasodilation reduces pulmonary artery pressure - the basis for PAH treatment.
Off-label endothelial benefits: PDE5 is expressed in systemic vasculature (lower than in target tissues but functionally relevant). Daily PDE5 inhibition improves systemic endothelial function via sustained NO/cGMP signaling. This may explain cardiovascular benefits seen in observational studies.
Workout performance: improved blood flow during exercise enhances oxygen delivery to muscles, supporting endurance and recovery. Anecdotal reports of improved 'pumps' and reduced muscle fatigue.
Long half-life (~17.5 hours) provides sustained effect - on-demand 10-20mg lasts 24-36 hours; daily 2.5-5mg provides continuous baseline.
Days 1-5: Building to steady state (daily) or acute effect (on-demand).
Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.
Exact-molecule evidence boundary: the live abstract reports the quoted finding for Tadalafil; no broader inference is made.
To examine the therapeutic effects of tadalafil on erectile dysfunction (ED) at 24 and 36 hours after dosing.
Evidence scope. Exact molecule wording appears in the quoted live sentence. Only the population/model, formulation, route, and outcome expressly stated there are supported.
Claims we could not support
No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.
Dose/route: 5mg daily (Cialis daily) OR 10mg on-demand; Oral; Once daily OR as needed. No selected live abstract sentence verified this complete regimen.
Mechanism as written in source JSON. No selected live abstract sentence verified the complete mechanism at the card formulation/route and relevant population/model.
Primary safety claim as written in source JSON. No selected live abstract sentence verified the complete safety claim for this exact formulation and route.
Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.
Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.
(terminal). Long half-life is the key distinguishing feature vs other PDE5 inhibitors.
Fasted (slightly delayed with food but bioavailability unchanged).
On-demand effect lasts 24-36 hours per dose. Daily dosing reaches steady state in ~5 days.
Not significantly affected by food (vs sildenafil which is reduced by fatty meals). Excellent oral bioavailability.
Acute: 24-36 hours per dose. Chronic daily: continuous baseline effect at steady state. Wash-out for nitrate compatibility: 48+ hours after last tadalafil dose.
Hepatic metabolism via CYP3A4 to inactive metabolites. Renal excretion of metabolites. Caution with CYP3A4 inhibitors/inducers.
Storage. Store at room temperature (15-30C) in a cool, dry place. Protect from light. Tablets shelf-stable 2-3 years.
PRESCRIPTION REQUIRED in the US. Generic tadalafil widely available since 2018 (significant cost reduction). FDA-approved for ED (Cialis), BPH (Cialis), and PAH (Adcirca 40mg daily). Off-label use for cardiovascular optimization is common but requires physician oversight.
Put it to work
Open Tadalafil straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Tadalafil in the app →Go deeper
The complete Tadalafil walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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