library.onepin.app/livagen Peptide Education Library
Education only, not medical advice 21+ Every dose is an example to finalize with a licensed provider
Bioregulators Khavinson bioregulator tetrapeptideNot FDA-approved · research compound

Livagen

Livagen (Khavinson)

200 mcg daily – 200 mcg SubQ 10 day course
Liver tissue regulatorHepatoprotective gene modulator

Livagen (Lys-Glu-Asp-Ala) is a Khavinson bioregulator tetrapeptide targeting hepatic (liver) tissue gene expression. It supports hepatocyte function, liver detoxification pathways, and hepatic regeneration. Developed for age-related liver function decline and hepatoprotection.

Quick Start
Route
SubQ injection
Start low
200 mcg SubQ
Frequency
10 day course
Timing
No fasting required

Starting dose. 200 mcg — Daily

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Conservative start
200 mcg daily · SubQ injection · 10 day course
conservative starter
200 mcg daily
10 day course
Intermediate
Hepatic DNA Decondensation
200 mcg · SubQ · Daily
in vitro · Khavinson, Lezhava et al. 2002 (Bulletin of Experimental Biology and Medicine, 134:389-392)
Closely related to Epithalon. Used for deep epigenetic resets. Human use has been published, but almost entirely by a single research group in Russian-language journals. None of it is registered on any trial registry and most reports were unblinded, so this evidence is far weaker than a controlled trial.
200 mcg
Daily
Reconstitution CalculatorU-100
050100u
Draw to
units
01

How it works

Livagen modulates gene expression in hepatocytes, upregulating genes involved in Phase I/II detoxification enzymes, albumin synthesis, bile acid metabolism, and hepatic regeneration. Supports liver tissue maintenance at the gene expression level.

02

What to expect

Early
Days 1–7

Days 1-10: Gene changes initiated.

Mid
Weeks 2–4

Weeks 2-8: Hepatic gene programs established.

Later
Weeks 4–12

Months: Sustained liver support.

03

Evidence

HumanPresent
AnimalPresent
In-vitroPresent

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

Evidence boundary from the checked abstract: Livagen and Epitalon inhibited enkephalin-degrading enzymes from human serum.

Livagen and Epitalon inhibited enkephalin-degrading enzymes from human serum.

[Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum]. Izvestiia Akademii nauk. Seriia biologicheskaia · 2003 · PMID 12942748

Evidence scope. This entry supports only the exact statement quoted from the live abstract; it does not independently verify OnePin's displayed dose, route, frequency, formulation, population, or broader mechanism.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: 200 mcg daily; SubQ injection; 10 day course. No checked live PubMed abstract verified this exact displayed dose, route, and frequency for the same molecule/formulation and relevant population.

Primary safety claim: No primary safety text present in source JSON. No checked live PubMed abstract directly verified this source-JSON safety claim at the displayed formulation, route, and regimen.

04

The honest take

Hepatoprotection

Bioregulatory gene expression modulation targeting liver-specific pathways. Russian clinical support.

05

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

Pin alone. Livagen must not share a syringe with anything else, whatever the pharmacology says. PIN ALONE. Khavinson bioregulator.

Documented together

GlutathioneLivagen targets liver gene expression, Glutathione is the primary liver detoxification antioxidant. Complementary hepatic support. Pin separately.
OvagenBoth target liver/GI tissue. Livagen focuses on hepatocytes, Ovagen on broader hepatic/GI tissue. Can run in sequence.

Keep separate

GHK-CuCopper degrades bioregulators.

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

06

Side effects & safety

Commonly reported

  • Very well tolerated
  • Mild injection site irritation

Less common & notes

  • Excellent safety profile.
07

Pharmacokinetics

Illustrative plasma concentration · 2.0 h
Half-life
0.5h
Peak · Tmax
0.05h
Elimination
2.5h
Bioavailability
~100%

SubQ

Duration of action
24-48 hours

Gene expression changes persist beyond peptide clearance

Clearance

Enzymatic degradation (peptidases)

Storage. Standard BAC water 2-8C. 21-28 days.

08

Regulatory status

Not FDA-approved. Research peptide.

Put it to work

Calculate, log & track

Open Livagen straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Livagen in the app →

Go deeper

The guide & community

The complete Livagen walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
Open in app Community

Track it in OnePin. Log vials, draws, and protocols in the app.