library.onepin.app/livagen Peptide Education Library

Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Bioregulators

Bioregulators Khavinson bioregulator tetrapeptide Not FDA-approved · investigational

Livagen

Livagen (Khavinson)

Khavinson bioregulator tetrapeptideLiver tissue regulatorHepatoprotective gene modulator

Livagen (Lys-Glu-Asp-Ala) is a Khavinson bioregulator tetrapeptide targeting hepatic (liver) tissue gene expression. It supports hepatocyte function, liver detoxification pathways, and hepatic regeneration. Developed for age-related liver function decline and hepatoprotection.

Quick Start

Route

SubQ injection

Start low

5 mg daily

Frequency

Daily for 10-20 day course

Timing

No fasting required

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Quick Start

Conservative start

5 mg daily · SubQ injection · Daily for 10-20 day course

Lowest starting point. Hold about a week to assess tolerance before stepping up.

5 mg daily

Daily for 10-20 day course

Intermediate

Hepatic DNA Decondensation

1-2 mg · SubQ · Daily

in vitro · Khavinson, Lezhava et al. 2002 (Bulletin of Experimental Biology and Medicine, 134:389-392)

1-2 mg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Target dose

050100u

Draw to

— units

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How it works

Livagen modulates gene expression in hepatocytes, upregulating genes involved in Phase I/II detoxification enzymes, albumin synthesis, bile acid metabolism, and hepatic regeneration. Supports liver tissue maintenance at the gene expression level.

What to expect

Early

Days 1–7

Days 1-10: Gene changes initiated.

Mid

Weeks 2–4

Weeks 2-8: Hepatic gene programs established.

Later

Weeks 4–12

Months: Sustained liver support.

Evidence

HumanPresent

AnimalPresent

In-vitroPresent

2002Effects of Livagen peptide on chromatin activation in lymphocytes from old people · Lezhava T et al, Bulletin of Experimental Biology and Medicine ↗peer reviewed

2006Anti-aging peptide bioregulators induce reactivation of chromatin · Khavinson VKh et al, Bulletin of Experimental Biology and Medicine ↗peer reviewed

The honest take

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Hepatoprotection

Bioregulatory gene expression modulation targeting liver-specific pathways. Russian clinical support.

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Safe & synergistic

GlutathioneLivagen targets liver gene expression, Glutathione is the primary liver detoxification antioxidant. Complementary hepatic support. Pin separately.

OvagenBoth target liver/GI tissue. Livagen focuses on hepatocytes, Ovagen on broader hepatic/GI tissue. Can run in sequence.

Keep separate

ALL (syringe)PIN ALONE. Khavinson bioregulator.

GHK-CuCopper degrades bioregulators.

Side effects & safety

Commonly reported

Very well tolerated
Mild injection site irritation

Less common & notes

Excellent safety profile.

Pharmacokinetics

Illustrative plasma concentration · 24 h

Half-life

0.5h

Peak · Tmax

0.05h

Elimination

2.5h

Activity

24-48 hours (gene expression changes persist beyond peptide clearance)

Storage. Standard BAC water 2-8C. 21-28 days.

Regulatory status

Not FDA-approved. Research peptide.

Put it to work

Calculate, log & track

Open Livagen straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Livagen in the app →

Go deeper

The guide & community

The complete Livagen walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

Open in app Community