Livagen (Lys-Glu-Asp-Ala) is a Khavinson bioregulator tetrapeptide targeting hepatic (liver) tissue gene expression. It supports hepatocyte function, liver detoxification pathways, and hepatic regeneration. Developed for age-related liver function decline and hepatoprotection.
Quick Start
Route
SubQ injection
Start low
200 mcg SubQ
Frequency
10 day course
Timing
No fasting required
Starting dose. 200 mcg — Daily
SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.
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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
Tiered Protocols · lowest first
Conservative start
200 mcg daily · SubQ injection · 10 day course
conservative starter
200 mcg daily
10 day course
Intermediate
Hepatic DNA Decondensation
200 mcg · SubQ · Daily
in vitro · Khavinson, Lezhava et al. 2002 (Bulletin of Experimental Biology and Medicine, 134:389-392)
Closely related to Epithalon. Used for deep epigenetic resets. Human use has been published, but almost entirely by a single research group in Russian-language journals. None of it is registered on any trial registry and most reports were unblinded, so this evidence is far weaker than a controlled trial.
200 mcg
Daily
Reconstitution CalculatorU-100
050100u
Draw to
— units
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01
How it works
Livagen modulates gene expression in hepatocytes, upregulating genes involved in Phase I/II detoxification enzymes, albumin synthesis, bile acid metabolism, and hepatic regeneration. Supports liver tissue maintenance at the gene expression level.
02
What to expect
Early
Days 1–7
Days 1-10: Gene changes initiated.
Mid
Weeks 2–4
Weeks 2-8: Hepatic gene programs established.
Later
Weeks 4–12
Months: Sustained liver support.
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Evidence
HumanPresent
AnimalPresent
In-vitroPresent
Each reference below was re-fetched from its PubMed record, and the quoted sentence was
confirmed to appear in that abstract and to support the claim it sits under. Follow any of
them to read the source.
Evidence boundary from the checked abstract: Livagen and Epitalon inhibited enkephalin-degrading enzymes from human serum.
Livagen and Epitalon inhibited enkephalin-degrading enzymes from human serum.
Evidence scope. This entry supports only the exact statement quoted from the live abstract; it does not independently verify OnePin's displayed dose, route, frequency, formulation, population, or broader mechanism.
Claims we could not support
No abstract we checked supports these for this molecule at this route. That is not the
same as saying they are false — it marks where the evidence is missing.
Dose/route: 200 mcg daily; SubQ injection; 10 day course. No checked live PubMed abstract verified this exact displayed dose, route, and frequency for the same molecule/formulation and relevant population.
Primary safety claim: No primary safety text present in source JSON. No checked live PubMed abstract directly verified this source-JSON safety claim at the displayed formulation, route, and regimen.
Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.
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Pin alone. Livagen must not share a syringe with anything else, whatever the pharmacology says.
PIN ALONE. Khavinson bioregulator.
Documented together
GlutathioneLivagen targets liver gene expression, Glutathione is the primary liver detoxification antioxidant. Complementary hepatic support. Pin separately.
OvagenBoth target liver/GI tissue. Livagen focuses on hepatocytes, Ovagen on broader hepatic/GI tissue. Can run in sequence.
Keep separate
GHK-CuCopper degrades bioregulators.
Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.