Bioregulators Khavinson bioregulator tetrapeptideNot FDA-approved · research compound

Cortagen

Cortagen (Khavinson)

Evidence: Studied in humans. Example dose: finalize with a provider. Not a fact-check stamp.

100 mcg daily SubQ 10-20 day course, 2-4x per year

10-20 mg Oral Daily

Cerebral cortex regulatorNeuroprotective gene modulator

Cortagen (Ala-Glu-Asp-Pro) is a Khavinson bioregulator tetrapeptide targeting cerebral cortex gene expression. It supports neuronal function, synaptic plasticity, and neuroprotective pathways in cortical tissue. Developed for age-related cognitive decline and cortical function restoration.

Quick Start

Route

SubQ injection

Start low

100 mcg SubQ

Frequency

10-20 day course, 2-4x per year

Timing

No fasting required

Starting dose. 100 mcg — Daily

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Conservative start

100 mcg daily · SubQ injection · 10-20 day course, 2-4x per year

conservative starter

100 mcg daily

10-20 day course, 2-4x per year

Standard

Neurological Recovery (Oral capsule)

10-20 mg · Oral · Daily

animal study · Turchaninova et al. 2000 (Bull Exp Biol Med, 130:1172-1174)

Oral dosing is standard, though SubQ (1-2mg) is utilized in the community for acute nerve healing. Human use has been published, but almost entirely by a single research group in Russian-language journals. None of it is registered on any trial registry and most reports were unblinded, so this evidence is far weaker than a controlled trial. This is the ORAL capsule dose and is not an injection dose. Oral peptide absorption is poor, so this figure is far higher than the injectable protocol on purpose. Do not inject this amount.

10-20 mg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Vials in this mix

Syringe size

Target dose

050100u

Draw to

— units

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I will split this dose across more than one syringe

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How it works

Cortagen modulates gene expression in cortical neurons, supporting synaptic plasticity genes, neurotransmitter receptor expression, and neuroprotective pathway activation. Works through direct DNA interaction at low concentrations.

What to expect

Early

Days 1–7

Days 1-10: Gene changes initiated.

Mid

Weeks 2–4

Weeks 2-8: Cortical gene programs established.

Later

Weeks 4–12

Months: Sustained neuroprotective support.

Evidence

HumanPresent

AnimalPresent

In-vitroPresent

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Quick-start dose/route: 100 mcg SubQ daily for 10-20 days. No checked abstract administered Cortagen subcutaneously at this dose. PMID 11276314 used 10 microg/kg intramuscularly in rats for 10 days.

Mechanism: direct DNA interaction and cortical-neuron gene-expression modulation. No checked abstract matched tissue/population. PMID 15159690 measured mouse-heart gene expression; PMID 11713572 measured rat cortex-explant growth.

Primary safety: very well tolerated with only mild injection-site irritation. No human safety abstract for the displayed SubQ regimen was found.

The honest take

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Cortical rejuvenation

Bioregulatory gene expression modulation in cortical tissue. Russian clinical support.

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

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Pin alone. Cortagen must not share a syringe with anything else, whatever the pharmacology says. PIN ALONE. Khavinson bioregulator.

Documented together

SemaxCortagen targets cortical gene expression, Semax enhances BDNF/neuroplasticity. Complementary cognitive support. Pin separately.

PinealonBoth target CNS through different bioregulatory pathways. Can run in sequence.

Keep separate

GHK-CuCopper degrades bioregulators.

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

Side effects & safety

Commonly reported

Very well tolerated
Mild injection site irritation

Less common & notes

Excellent safety profile.

Pharmacokinetics

Illustrative plasma concentration · 2.0 h

Half-life

0.5h

Peak · Tmax

0.05h

Elimination

2.5h

Bioavailability

~100%

SubQ

Duration of action

Weeks to months (cortical gene expression changes persist long after peptide clearance)

Clearance

Rapid enzymatic degradation (peptidases); renal excretion of amino acid components

Storage. Standard BAC water 2-8C. 21-28 days.

Regulatory status

Not FDA-approved. Research peptide.

Put it to work

Calculate, log & track

Open Cortagen straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Cortagen in the app →

Go deeper

The guide & community

The complete Cortagen walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

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