library.onepin.app/cortagen Peptide Education Library
Education only, not medical advice 21+ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Bioregulators

Bioregulators Khavinson bioregulator tetrapeptide Not FDA-approved · investigational

Cortagen

Cortagen (Khavinson)

Khavinson bioregulator tetrapeptideCerebral cortex regulatorNeuroprotective gene modulator

Cortagen (Ala-Glu-Asp-Pro) is a Khavinson bioregulator tetrapeptide targeting cerebral cortex gene expression. It supports neuronal function, synaptic plasticity, and neuroprotective pathways in cortical tissue. Developed for age-related cognitive decline and cortical function restoration.

Quick Start
Route
SubQ injection
Start low
5 mg daily
Frequency
Daily for 10-20 day course
Timing
No fasting required

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
5 mg daily · SubQ injection · Daily for 10-20 day course
Lowest starting point. Hold about a week to assess tolerance before stepping up.
5 mg daily
Daily for 10-20 day course
Standard
Neurological Recovery
10-20 mg · Oral · Daily
animal study · Turchaninova et al. 2000 (Bull Exp Biol Med, 130:1172-1174)
10-20 mg
Daily
Reconstitution CalculatorU-100
050100u
Draw to
units
01

How it works

Cortagen modulates gene expression in cortical neurons, supporting synaptic plasticity genes, neurotransmitter receptor expression, and neuroprotective pathway activation. Works through direct DNA interaction at low concentrations.

Cortagen modulates gene expression in cortical neurons, supporting synaptic plasticity genes, neurotransmitter receptor expression, and neuroprotective pathway activation. Works through direct DNA interaction at low concentrations.

02

What to expect

Early
Days 1–7

Days 1-10: Gene changes initiated.

Mid
Weeks 2–4

Weeks 2-8: Cortical gene programs established.

Later
Weeks 4–12

Months: Sustained neuroprotective support.

03

Evidence

HumanPresent
AnimalPresent
In-vitroPresent
2004Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray · Anisimov SV, Khavinson VKh, Anisimov VN, Neuro Endocrinology Letters ↗peer reviewed
2000Effect of tetrapeptide cortagen on regeneration of sciatic nerve · Turchaninova LN, Kolosova LI, Malinin VV, et al, Bulletin of Experimental Biology and Medicine ↗peer reviewed
2010Peptide bioregulation of aging: results and prospects · Anisimov VN, Khavinson VKh, Biogerontology ↗review
2009Peptide regulation of aging: 35-year research experience · Khavinson VKh, Anisimov VN, Bulletin of Experimental Biology and Medicine ↗review
04

The honest take

Cortical rejuvenation

Bioregulatory gene expression modulation in cortical tissue. Russian clinical support.

05

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Safe & synergistic

SemaxCortagen targets cortical gene expression, Semax enhances BDNF/neuroplasticity. Complementary cognitive support. Pin separately.
PinealonBoth target CNS through different bioregulatory pathways. Can run in sequence.

Keep separate

ALL (syringe)PIN ALONE. Khavinson bioregulator.
GHK-CuCopper degrades bioregulators.
06

Side effects & safety

Commonly reported

  • Very well tolerated
  • Mild injection site irritation

Less common & notes

  • Excellent safety profile.
07

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
0.5h
Peak · Tmax
0.05h
Elimination
2.5h
Activity
Weeks to months (cortical gene expression changes persist long after peptide clearance)

Storage. Standard BAC water 2-8C. 21-28 days.

08

Regulatory status

Not FDA-approved. Research peptide.

Put it to work

Calculate, log & track

Open Cortagen straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Cortagen in the app →

Go deeper

The guide & community

The complete Cortagen walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
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