library.onepin.app/dihexa Peptide Education Library

Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Cognitive & Mood

Cognitive & Mood Synthetic angiotensin IV analog Not FDA-approved · investigational

Dihexa

PNB-0408

Synthetic angiotensin IV analogHGF/c-Met pathway activatorUltra-potent nootropicSynaptogenesis promoter

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic peptide derived from angiotensin IV that acts as an extremely potent nootropic compound. Published research from Washington State University demonstrated Dihexa is approximately 10 million times more potent than BDNF at promoting hepatocyte growth factor (HGF) signaling, which drives synaptogenesis (new synapse formation) in the hippocampus. It crosses the blood-brain barrier and enhances cognitive function through HGF/c-Met receptor pathway activation.

Quick Start

Route

SubQ or oral

Start low

5-20 mg

Frequency

Daily

Timing

No data

Morning dosing preferred for cognitive effects during the day. No fasting required. Very potent - start with lowest dose.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Quick Start

Conservative start

5-20 mg · SubQ or oral · Daily

Lowest starting point. Hold about a week to assess tolerance before stepping up.

5-20 mg

Daily

Expert

Synaptogenic Protocol

10-20 mg · Oral · Weekly

animal study · McCoy/Harding et al. 2012 (J Pharmacol Exp Ther 344:141-54)

10-20 mg

Weekly

Reconstitution CalculatorU-100

Vial strength

BAC water

Target dose

050100u

Draw to

— units

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How it works

Dihexa stabilizes hepatocyte growth factor (HGF) at the c-Met receptor, preventing HGF degradation by hepatocyte growth factor activator inhibitor-1 (HAI-1). This prolongs HGF/c-Met signaling which drives synaptogenesis, dendritic spine formation, and neural connectivity in the hippocampus. The extraordinary potency (10 million times BDNF) comes from this stabilization mechanism rather than direct receptor activation.

What to expect

Early

Days 1–7

Days 1-7: Possible subtle cognitive improvements.

Mid

Weeks 2–4

Weeks 2-4: Synaptogenesis effects accumulate.

Later

Weeks 4–12

Weeks 4-8: Full cognitive enhancement.

Evidence

HumanNo published trials

AnimalPresent

In-vitroPresent

2015The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease · Wright JW, Harding JW, Journal of Alzheimer's Disease ↗review

2022Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer's Disease: Randomized, Placebo-Controlled, Double-Blind, Phase I Clinical Trial · Hayashi Y, Jin K, Frautschy SA, et al, Journal of Alzheimer's Disease ↗peer reviewed

2014Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure · Coffin AB, May LA, Wright JW, et al, Frontiers in Cellular Neuroscience ↗peer reviewed

The honest take

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10 million times more potent than BDNF

Published research claim. Refers to HGF stabilization potency at c-Met receptor, not direct comparison of nootropic effects. The potency comparison is mechanistic, not clinical.

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Safe & synergistic

BPC-157Non-overlapping

SS-31Cognitive + mitochondrial

HumaninCognitive + neuroprotection

P-21Both nootropic, different mechanisms

Keep separate

CJC-1295 with DACDAC maleimide.

Side effects & safety

Commonly reported

Limited data
Generally reported as well tolerated

Less common & notes

HGF/c-Met pathway is involved in cancer biology (c-Met is a proto-oncogene).
Theoretical concern about promoting cancer cell growth.
Not studied long-term.
Use with caution.

Pharmacokinetics

Illustrative plasma concentration · 24 h

Half-life

Peak · Tmax

0.5h

Elimination

10h

Activity

12-24 hours (HGF/c-Met signaling and synaptogenesis effects persist beyond plasma clearance)

Storage. Standard BAC water 2-8C. 28 days.

Regulatory status

Research compound only. Not FDA-approved. Not clinically tested in humans.

Put it to work

Calculate, log & track

Open Dihexa straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Dihexa in the app →

Go deeper

The guide & community

The complete Dihexa walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

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