library.onepin.app/turkey-tail Peptide Education Library

Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Immune

Immune Trametes versicolor (Coriolus versicolor)

Turkey Tail

Trametes versicolor · Coriolus versicolor

Trametes versicolor (Coriolus versicolor)PSK / PSP Protein-Bound Beta-GlucansJapan-Approved Cancer AdjunctDietary Supplement (US)

Turkey Tail (Trametes versicolor / Coriolus versicolor) is one of the most-researched medicinal mushrooms in Asia, particularly in Japan and China for cancer adjunct therapy. Active compounds are PSK (Polysaccharide K, krestin) and PSP (Polysaccharide Peptide) - protein-bound beta-glucans. PSK has been an FDA-equivalent approved adjunctive cancer therapy in Japan since 1977.

Quick Start

Route

Oral capsule, powder, or extract

Start low

1-3g daily

Frequency

1-3x daily

Timing

Independent

Divided doses preferred for cancer adjunct.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Quick Start

Conservative start

1-3g daily · Oral capsule, powder, or extract · 1-3x daily

Lowest starting point. Hold about a week to assess tolerance before stepping up.

1-3g daily

1-3x daily

Standard

PSK/PSK Immune Therapy

1-3 g · Oral · Daily

human clinical trial · Torkelson et al. 2012 (ISRN Oncology)

1-3 g

Daily

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How it works

PSK and PSP drive Turkey Tail's effects:

PSK (Polysaccharide K / Krestin)

Protein-bound beta-glucan that activates immune system via dendritic cells, macrophages, NK cells, and T-cells. Reduces tumor growth in animal models and improves immune function in cancer patients.

PSP (Polysaccharide Peptide)

Similar mechanism, isolated from different Coriolus strain.

Cancer Survival

Japanese trials show improved 5-year survival in gastric and colorectal cancer when PSK is added to standard chemotherapy.

Microbiome

Beta-glucans modulate gut microbiota - prebiotic effect.

What to expect

Early

Days 1–7

Days 1-14: subtle subjective effects.

Mid

Weeks 2–4

Weeks 2-12: peak immune effects.

Later

Weeks 4–12

Long-term continuous use OK.

Evidence

HumanStrong

AnimalStrong

In-vitroPresent

2007PSK (Krestin) survival benefit in gastric cancer · Oba K et al, Cancer Immunology, Immunotherapy ↗review

2011Polysaccharide K and Coriolus versicolor extracts for lung cancer · Wong CK et al, Cochrane Database ↗review

2008Turkey Tail mushroom (Trametes versicolor) immune-modulating effects · Standish LJ et al, Integrative Cancer Therapies ↗peer reviewed

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

Side effects & safety

Commonly reported

Mild GI
Mild headache (rare)

Less common & notes

Allergic reactions rare.
Long-term safety excellent per Japanese pharmaceutical use of PSK.

Pharmacokinetics

Illustrative plasma concentration · 24 h

Half-life

Variable

Peak · Tmax

1-3 hours

Elimination

Cumulative effects over weeks

Activity

Daily dosing for sustained effects

Storage. Capsule/powder. Cool dry location.

Regulatory status

PSK is pharmaceutical drug in Japan. Dietary supplement (US, DSHEA).

Put it to work

Calculate, log & track

Open Turkey Tail straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Turkey Tail in the app →

Go deeper

The guide & community

The complete Turkey Tail walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

Open in app Community