library.onepin.app/bee-propolis Peptide Education Library
OnePin Peptide Library
Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Immune

Immune Bee-Produced Resinous Substance

Bee Propolis

Propolis · Bee Glue

Bee-Produced Resinous SubstanceAntimicrobial / Anti-InflammatoryCAPE / Flavonoid BioactivesDietary Supplement

Bee Propolis is a resinous substance produced by bees from plant resins, beeswax, and bee saliva. Bees use it to seal hive cracks and as antimicrobial protection. Composition varies dramatically by geographic source - Brazilian Green Propolis (Baccharis-derived), Brazilian Red Propolis (Dalbergia-derived), and European Poplar Propolis are the three major commercially-available types, each with distinct chemistry.

Quick Start
Route
Oral capsule, tincture, or topical
Start low
200-1000mg daily
Frequency
1-3x daily
Timing
Independent

Independent.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
200-1000mg daily · Oral capsule, tincture, or topical · 1-3x daily
Lowest starting point. Hold about a week to assess tolerance before stepping up.
200-1000mg daily
1-3x daily
Standard
Antimicrobial & Immune Defense
500 mg · Oral · Daily
human clinical trial · Silveira et al. 2021 (Biomedicine & Pharmacotherapy, vol. 138)
500 mg
Daily
◆
01

How it works

Propolis bioactives drive multiple effects:

CAPE (Caffeic Acid Phenethyl Ester)

Major bioactive in European Poplar Propolis. NF-κB inhibitor with anti-inflammatory, anti-tumor, and immunomodulating effects.

Flavonoids

Galangin, chrysin, pinocembrin, etc. - antioxidant, antibacterial, antiviral.

Antimicrobial

Direct activity against bacteria (S. mutans, S. aureus), viruses (herpes simplex), and fungi (Candida).

Anti-Inflammatory

NF-κB modulation, COX inhibition.

Geographic Variation

Brazilian Green Propolis is rich in artepillin C; Brazilian Red Propolis is rich in retusapurpurin and isoflavones; European Propolis is rich in CAPE. Different applications may favor different types.

02

What to expect

Early
Days 1–7

Days 1-7: subtle effects.

Mid
Weeks 2–4

Weeks 1-4: peak benefits.

Later
Weeks 4–12

Long-term continuous use OK.

03

Evidence

HumanPresent
AnimalStrong
In-vitroPresent
2017Therapeutic effects of propolis on oral diseases · Khurshid Z et al, Bioactive Carbohydrates and Dietary Fibre ↗review
2011Brazilian Green Propolis: anticancer and antiviral activity · Sforcin JM, Bankova V, Journal of Ethnopharmacology ↗review
2007Propolis and immune function · Sforcin JM, Journal of Ethnopharmacology ↗review
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

05

Side effects & safety

Commonly reported

  • Mild GI
  • Mild allergic skin reactions
  • Oral irritation (tincture form)

Less common & notes

  • ANAPHYLAXIS in bee-allergic individuals.
  • Antiplatelet activity.
  • Allergic dermatitis from topical use.
06

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
Variable
Peak · Tmax
1-3 hours
Elimination
Hours plasma; cumulative effects over weeks
Activity
Daily dosing for sustained effects

Storage. Capsule/tincture. Cool dry location.

07

Regulatory status

Dietary supplement (US, DSHEA). Some pharmaceutical use in Eastern Europe.

Put it to work

Calculate, log & track

Open Bee Propolis straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Bee Propolis in the app →

Go deeper

The guide & community

The complete Bee Propolis walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
Open in app Community