OnePin Peptide Library · Immune
Reishi
Ganoderma lucidum · Ling Zhi
Reishi (Ganoderma lucidum, also known as Lingzhi in Chinese) is a medicinal fungus with a 2,000+ year history in Traditional Chinese Medicine. Often called the 'mushroom of immortality' for its longevity claims. Active compounds include β-glucans (immune modulators), triterpenes (ganoderic acids - anti-inflammatory, hepatoprotective), and ergosterol derivatives.
Evening dosing for sleep support; morning for adaptogen use.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Reishi acts through multiple bioactive families:
β-Glucans
Activate dendritic cells and macrophages via Dectin-1 and complement receptor 3 - shifts immune balance toward Th1 in infection contexts and modulates inappropriate Th2/Th17 in autoimmune contexts.
Triterpenes (Ganoderic Acids)
Anti-inflammatory via NF-κB modulation; hepatoprotective via antioxidant and Phase 2 detoxification enzyme upregulation.
Ergosterol Derivatives
Vitamin D2 precursors; modulate inflammation.
Calming / Sleep Effects
Mechanism less clear but consistent in clinical trials. May involve GABAergic modulation and sleep architecture improvement.
Long-Term Tonic
Effects accumulate over weeks-to-months; not an acute therapy.
What to expect
Days 1-14: subtle subjective effects.
Weeks 2-8: peak adaptogen and immune-modulation effects.
Long-term: continuous use is traditional.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Keep separate
Side effects & safety
Commonly reported
- Mild GI upset
- Dry mouth
- Possible mild dizziness early
Less common & notes
- Allergic reactions to fungal protein.
- Theoretical bleeding risk (antiplatelet activity).
- Hepatic effects rare; case reports of hepatitis with high-dose chronic use exist - monitor LFTs in chronic high-dose users.
Pharmacokinetics
Storage. Capsule/powder. Cool, dry location.
Regulatory status
Dietary supplement (US). Traditional medicine in China and other Asian markets.
Put it to work
Calculate, log & track
Open Reishi straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Reishi in the app →Go deeper
The guide & community
The complete Reishi walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
Join the community ↗