Urtica dioica · Nettle Leaf · Stinging Nettle Root
Stinging Nettle (Urtica dioica) - the leaves and root have different applications. Nettle leaf is used for allergic rhinitis (mast cell stabilization), seasonal allergies, and as a nutrient-rich tonic. Nettle root is used for benign prostatic hyperplasia (BPH) symptoms and male hormonal balance via SHBG modulation.
Starting dose. 300-600mg — Standardized extract
Independent.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
Nettle leaf and root have distinct mechanisms:
Reduces histamine release from mast cells - mechanism for allergic rhinitis benefit.
Lignans in nettle root bind SHBG, theoretically displacing bound T to free T. Also may inhibit aromatase modestly.
Mild inhibition of T→DHT conversion - mechanism for BPH benefit.
Both leaf and root reduce pro-inflammatory cytokines.
Nettle leaf is rich in iron, magnesium, calcium, B-vitamins, vitamin K - traditional 'spring tonic.'
Days 1-14: subtle subjective effects.
Weeks 4-12: peak benefits.
Long-term continuous use OK.
Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.
Stinging nettle root and leaf extracts were tested for their effect on prostatic smooth muscle contractility.
Stinging nettle root and leaf extracts were tested for their effect on prostatic smooth muscle contractility.
Evidence scope. Ex-vivo/in-vitro work on root and leaf extracts; not a clinical oral-dose study.
Claims we could not support
No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.
Dose/route: 300-600mg standardized extract via Oral capsule, tea, or tincture, 1-3x daily. No checked live PubMed abstract supported this complete molecule/formulation/route/dose/frequency combination.
Primary safety claim: Mild GI. No checked live abstract directly established this as the primary concern for the card's exact formulation and regimen.
Variable
Hours plasma; cumulative effects over weeks
Oral moderate
Daily dosing for sustained effects
Hepatic and renal
Storage. Capsule/tea/tincture. Cool dry location.
Dietary supplement (US, DSHEA).
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