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OnePin Peptide Library · Hormonal

Hormonal Urtica dioica (Leaves and Root - Different Uses)

Stinging Nettle

Urtica dioica · Nettle Leaf · Stinging Nettle Root

Urtica dioica (Leaves and Root - Different Uses)Allergic Rhinitis / BPH / T-SupportAnti-Inflammatory BotanicalDietary Supplement

Stinging Nettle (Urtica dioica) - the leaves and root have different applications. Nettle leaf is used for allergic rhinitis (mast cell stabilization), seasonal allergies, and as a nutrient-rich tonic. Nettle root is used for benign prostatic hyperplasia (BPH) symptoms and male hormonal balance via SHBG modulation.

Quick Start
Route
Oral capsule, tea, or tincture
Start low
300-600mg standardized extract
Frequency
1-3x daily
Timing
Independent

Independent.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
300-600mg standardized extract · Oral capsule, tea, or tincture · 1-3x daily
Lowest starting point. Hold about a week to assess tolerance before stepping up.
300-600mg standardized extract
1-3x daily
Standard
SHBG Modulation
400-600 mg · Oral · Daily
human study · Chrubasik et al. 2007 (Phytomedicine)
400-600 mg
Daily
◆
01

How it works

Nettle leaf and root have distinct mechanisms:

Leaf - Mast Cell Stabilization

Reduces histamine release from mast cells - mechanism for allergic rhinitis benefit.

Root - SHBG Binding

Lignans in nettle root bind SHBG, theoretically displacing bound T to free T. Also may inhibit aromatase modestly.

Root - 5-α-Reductase

Mild inhibition of T→DHT conversion - mechanism for BPH benefit.

Anti-Inflammatory

Both leaf and root reduce pro-inflammatory cytokines.

Nutrient Density

Nettle leaf is rich in iron, magnesium, calcium, B-vitamins, vitamin K - traditional 'spring tonic.'

02

What to expect

Early
Days 1–7

Days 1-14: subtle subjective effects.

Mid
Weeks 2–4

Weeks 4-12: peak benefits.

Later
Weeks 4–12

Long-term continuous use OK.

03

Evidence

HumanPresent
AnimalPresent
In-vitroPresent
2005Stinging nettle for BPH and prostate health · Safarinejad MR, Journal of Herbal Pharmacotherapy ↗peer reviewed
1990Efficacy of freeze-dried nettle for allergic rhinitis · Mittman P, Planta Medica ↗peer reviewed
2018Urtica dioica (Stinging Nettle) - a herb for all seasons · Kregiel D et al, Molecules ↗review
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

05

Side effects & safety

Commonly reported

  • Mild GI
  • Mild diuretic effect

Less common & notes

  • Allergic skin reactions.
  • Mild hypoglycemia in diabetics.
  • Vitamin K interactions with warfarin.
  • Long-term safety good.
06

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
Variable
Peak · Tmax
1-3 hours
Elimination
Hours plasma; cumulative effects over weeks
Activity
Daily dosing for sustained effects

Storage. Capsule/tea/tincture. Cool dry location.

07

Regulatory status

Dietary supplement (US, DSHEA).

Put it to work

Calculate, log & track

Open Stinging Nettle straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Stinging Nettle in the app →

Go deeper

The guide & community

The complete Stinging Nettle walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
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