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OnePin Peptide Library · Hormonal

Hormonal Fadogia agrestis (West African Shrub)

Fadogia Agrestis

Fadogia

Fadogia agrestis (West African Shrub)Testosterone Support (Limited Evidence)Libido BotanicalDietary Supplement (Limited Safety Data)

Fadogia Agrestis is a West African shrub (Rubiaceae family) traditionally used for libido and male vitality. Gained Western prominence after Andrew Huberman cited it as part of his 'Tongkat Ali + Fadogia' stack for testosterone support. Active compounds include alkaloids and saponins.

Quick Start
Route
Oral capsule
Start low
300-450mg
Frequency
1-2x daily
Timing
With food typically

Morning typical.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
300-450mg · Oral capsule · 1-2x daily
Lowest starting point. Hold about a week to assess tolerance before stepping up.
300-450mg
1-2x daily
Standard
Testosterone Support Cycle
400-600 mg · Oral · Daily
animal study · Yakubu et al. 2005 (Asian J Androl)
400-600 mg
Daily
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01

How it works

Fadogia Agrestis mechanism is incompletely characterized:

Putative LH Stimulation

Rodent studies suggest possible luteinizing hormone elevation, driving testicular T production.

Cytotoxic Concerns

Higher-dose rodent studies show testicular toxicity (reduced sperm count, damaged seminiferous tubules) - mechanism unclear, possibly via alkaloid content.

Saponins

Various saponin compounds may contribute to aphrodisiac and adaptogenic effects.

Insufficient Human Data

No published human RCTs as of this writing. All claims rest on rodent studies plus community/Huberman popularity.

02

What to expect

Early
Days 1–7

Weeks 1-2: subtle effects.

Mid
Weeks 2–4

Weeks 4-8: peak short-cycle effects.

Later
Weeks 4–12

Cycle off; safety data limits long-term continuous use.

03

Evidence

HumanNo published trials
AnimalPresent
In-vitroPresent
2008Aphrodisiac and androgenic activity of Fadogia agrestis stem · Yakubu MT et al, Asian Journal of Andrology ↗peer reviewed
2007Toxicity of Fadogia agrestis stem extract in male rats · Yakubu MT et al, Andrologia ↗peer reviewed
2014Effect of Fadogia agrestis stem on hormonal indices and serum gonadotropins · Watcho P et al, Pharmaceutical Biology ↗peer reviewed
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

05

Side effects & safety

Commonly reported

  • Mild GI
  • Possible mild stimulant effect

Less common & notes

  • Theoretical testicular toxicity from rodent data - not directly observed in humans but mechanism cause for caution.
  • Hypertension at high doses.
  • Long-term safety in humans uncharacterized.
  • Discontinue immediately for any testicular symptoms.
06

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
Variable, multi-component
Peak · Tmax
1-3 hours
Elimination
Hours plasma
Activity
Daily dosing during cycle

Storage. Capsule. Cool dry location.

07

Regulatory status

Dietary supplement (US, DSHEA). Limited Western regulatory oversight. Quality varies.

Put it to work

Calculate, log & track

Open Fadogia Agrestis straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Fadogia Agrestis in the app →

Go deeper

The guide & community

The complete Fadogia Agrestis walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
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