Fadogia
Fadogia Agrestis is a West African shrub (Rubiaceae family) traditionally used for libido and male vitality. Gained Western prominence after Andrew Huberman cited it as part of his 'Tongkat Ali + Fadogia' stack for testosterone support. Active compounds include alkaloids and saponins.
Morning typical.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
Fadogia Agrestis mechanism is incompletely characterized:
Rodent studies suggest possible luteinizing hormone elevation, driving testicular T production.
Higher-dose rodent studies show testicular toxicity (reduced sperm count, damaged seminiferous tubules) - mechanism unclear, possibly via alkaloid content.
Various saponin compounds may contribute to aphrodisiac and adaptogenic effects.
No published human RCTs as of this writing. All claims rest on rodent studies plus community/Huberman popularity.
Weeks 1-2: subtle effects.
Weeks 4-8: peak short-cycle effects.
Cycle off; safety data limits long-term continuous use.
Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.
Aqueous Fadogia stem extract increased rat blood testosterone, proposed to explain aphrodisiac effects.
The aqueous extract of Fadogia agrestis stem increased the blood testosterone concentrations and this may be the mechanism responsible for its aphrodisiac effects and various masculine behaviors.
Evidence scope. Animal; proposed mechanism; not LH evidence.
Oral aqueous stem extract adversely altered male-rat testicular-function indices.
The alterations brought about by the aqueous extract of Fadogia agrestis stem are indications of adverse effects on the male rat testicular function and this may adversely affect the functional capacities of the testes.
Evidence scope. Animal; 18-100 mg/kg/day for 28 days; not human safety.
Claims we could not support
No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.
Dose/route: 300-450 mg oral capsule 1-2x/day. No human trial validated this regimen.
Specific LH, sperm-count, and seminiferous-tubule claims. The checked abstracts did not state these specifics.
Human safety. No human clinical abstract was found.
Variable, multi-component
Hours plasma
Oral moderate
Daily dosing during cycle
Hepatic
Storage. Capsule. Cool dry location.
Dietary supplement (US, DSHEA). Limited Western regulatory oversight. Quality varies.
Put it to work
Open Fadogia Agrestis straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Fadogia Agrestis in the app →Go deeper
The complete Fadogia Agrestis walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
Join the community ↗Track it in OnePin. Log vials, draws, and protocols in the app.
Type a name, brand, or tool. Esc closes.