OnePin Peptide Library · Cognitive & Mood
Scopolamine Patch
Transderm Scop · Scopoderm · Scopolamine TTS
Transderm-Scop (scopolamine patch) is a 3-day transdermal delivery system containing 1.5 mg scopolamine, releasing approximately 1 mg over 72 hours. Applied behind the ear on hairless skin, it is used primarily for prevention of motion sickness and post-operative nausea and vomiting. IMPORTANT: This is a RESERVOIR-type patch with a rate-controlling membrane - it must NEVER be cut, as cutting destroys the membrane and causes dose dump. Patch must be removed before MRI due to its metal backing.
Apply behind one ear on hairless skin 4 hours before needed effect. Wash hands thoroughly after application to avoid eye contact (causes pupil dilation in the exposed eye).
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Scopolamine is a non-selective muscarinic acetylcholine receptor (mAChR) antagonist with activity at M1 receptors in the vestibular nuclei and vomiting center. By blocking cholinergic signaling in these central pathways, it dampens the nausea response to vestibular stimulation (motion) and interrupts afferent emetic signaling postoperatively. Its tertiary-amine structure allows it to cross the blood-brain barrier, giving it stronger central antiemetic effects than peripheral anticholinergics.
Scopolamine is a non-selective muscarinic acetylcholine receptor (mAChR) antagonist with activity at M1 receptors in the vestibular nuclei and vomiting center. By blocking cholinergic signaling in these central pathways, it dampens the nausea response to vestibular stimulation (motion) and interrupts afferent emetic signaling postoperatively. Its tertiary-amine structure allows it to cross the blood-brain barrier, giving it stronger central antiemetic effects than peripheral anticholinergics.
What to expect
0-4 hours: onset of effect
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Side effects & safety
Commonly reported
- Dry mouth (60-70%)
- Blurred vision (mydriasis in exposed eye)
- Drowsiness
- Urinary retention
Less common & notes
- Confusion (especially in elderly)
- Hallucinations
- Heat intolerance
- Constipation
Pharmacokinetics
Storage. Store pouched patches at room temperature (20-25C). Apply immediately upon opening. Aluminized backing means patch must be removed before MRI.
Regulatory status
FDA-approved for motion sickness and PONV. Prescription-only. Classified as anticholinergic - avoid in narrow-angle glaucoma, urinary retention, pyloric stenosis.
Put it to work
Calculate, log & track
Open Scopolamine Patch straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Scopolamine Patch in the app →Go deeper
The guide & community
The complete Scopolamine Patch walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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