OnePin Peptide Library · Longevity
Pomegranate Extract
Punica granatum Extract
Pomegranate (Punica granatum) is a fruit native to the Middle East and South Asia, used medicinally for over 5,000 years across multiple cultures. Pomegranate contains an exceptionally high concentration of polyphenols, especially punicalagins (the largest molecular weight polyphenols known) and ellagitannins, which are converted by gut bacteria into urolithins - particularly urolithin A. Urolithin A has emerged as one of the most exciting longevity compounds in recent years for its ability to stimulate mitophagy (selective clearance of damaged mitochondria).,Pomegranate's clinical research focuses on cardiovascular health (BP reduction, atherosclerosis regression in some trials), prostate cancer (PSA stabilization in early-stage), erectile function (NO-mediated effects), and emerging mitophagy/longevity applications via urolithin A. The Aviram lab in Israel has published extensively on pomegranate's antiatherogenic effects in human trials, showing reduced carotid intima-media thickness and oxidized LDL with daily pomegranate juice consumption.,Beyond pomegranate juice (which has high sugar content - 30-35g per cup), supplementation forms include pomegranate extract (standardized to 30-50% punicalagins), pomegranate seed oil (rich in punicic acid - a unique conjugated linolenic acid), and isolated urolithin A (Mitopure / Timeline brand). Standard pomegranate extract doses range from 250-1000mg daily, providing comparable polyphenol intake to 2-3 cups of pomegranate juice without the sugar load.
Pomegranate extract 500mg-1g daily with food. For direct mitophagy effect (bypassing gut bacteria variability), Mitopure urolithin A 250-500mg daily. Pairs naturally with omega-3, vitamin K2, and CoQ10 for cardiovascular protocol.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Pomegranate's primary active compounds are punicalagins (large polyphenols) and ellagitannins, which are hydrolyzed in the gut to ellagic acid and then converted by specific gut bacteria (especially Gordonibacter species) to urolithins - particularly urolithin A. Notably, only 30-40% of people have the gut bacteria to efficiently convert ellagitannins to urolithin A; this 'urolithin metabotype' partly explains inter-individual variability in pomegranate response. This led to the development of direct urolithin A supplementation (Mitopure) which bypasses the bacterial conversion step.,Urolithin A's most important mechanism is induction of mitophagy - the cellular process of selectively clearing damaged mitochondria. With age, accumulation of damaged mitochondria contributes to reduced cellular energy efficiency and various age-related dysfunctions. Urolithin A reactivates mitophagy through PINK1/Parkin pathway activation, leading to improved mitochondrial quality and function. Animal studies show urolithin A extends lifespan and improves muscle strength in aged mice.,Beyond urolithin A, pomegranate's whole polyphenol profile provides direct antioxidant effects (especially against oxidized LDL, which drives atherosclerosis), eNOS upregulation (improved endothelial function and erectile function), 5-alpha reductase inhibition (relevant for prostate health), and modulation of inflammatory pathways (NF-kB inhibition). Punicic acid in seed oil has additional effects on lipid metabolism and PPAR-gamma signaling.
Pomegranate's primary active compounds are punicalagins (large polyphenols) and ellagitannins, which are hydrolyzed in the gut to ellagic acid and then converted by specific gut bacteria (especially Gordonibacter species) to urolithins - particularly urolithin A. Notably, only 30-40% of people have the gut bacteria to efficiently convert ellagitannins to urolithin A; this 'urolithin metabotype' partly explains inter-individual variability in pomegranate response. This led to the development of direct urolithin A supplementation (Mitopure) which bypasses the bacterial conversion step.,Urolithin A's most important mechanism is induction of mitophagy - the cellular process of selectively clearing damaged mitochondria. With age, accumulation of damaged mitochondria contributes to reduced cellular energy efficiency and various age-related dysfunctions. Urolithin A reactivates mitophagy through PINK1/Parkin pathway activation, leading to improved mitochondrial quality and function. Animal studies show urolithin A extends lifespan and improves muscle strength in aged mice.,Beyond urolithin A, pomegranate's whole polyphenol profile provides direct antioxidant effects (especially against oxidized LDL, which drives atherosclerosis), eNOS upregulation (improved endothelial function and erectile function), 5-alpha reductase inhibition (relevant for prostate health), and modulation of inflammatory pathways (NF-kB inhibition). Punicic acid in seed oil has additional effects on lipid metabolism and PPAR-gamma signaling.
What to expect
Days 1-14: Anti-inflammatory effects.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Powders and capsules shelf-stable in cool, dry place. Pomegranate juice refrigerated, oxidizes once opened (consume within 5-7 days).
Regulatory status
Classified as a dietary supplement / food product. Pomegranate juice and extracts widely available. Mitopure (Timeline) has FDA NDIN status. Urolithin A is a Novel Food in EU.
Put it to work
Calculate, log & track
Open Pomegranate Extract straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
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The guide & community
The complete Pomegranate Extract walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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