library.onepin.app/pancragen Peptide Education Library

Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Bioregulators

Bioregulators Khavinson bioregulator pentapeptide Not FDA-approved · investigational

Pancragen

Pancragen (Khavinson)

Khavinson bioregulator pentapeptidePancreatic tissue regulatorBeta-cell function modulator

Pancragen (Lys-Glu-Asp-Trp-Pro) is a Khavinson bioregulator pentapeptide targeting pancreatic tissue gene expression. It supports beta-cell function, insulin secretion pathways, and pancreatic tissue maintenance. Relevant for age-related pancreatic decline and metabolic health optimization.

Quick Start

Route

SubQ injection

Start low

5 mg daily

Frequency

Daily for 10-20 day course

Timing

No fasting required

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Quick Start

Conservative start

5 mg daily · SubQ injection · Daily for 10-20 day course

Lowest starting point. Hold about a week to assess tolerance before stepping up.

5 mg daily

Daily for 10-20 day course

Standard

Pancreatic Islet Support

10-20 mg · Oral · Daily

human study · Korkushko OV, Khavinson VK, Shatilo VB, et al. Prospects of using pancragen for correction of metabolic disorders in elderly people. Bull Exp Biol Med. 2011;151(4):454-456. PMID 22448364.

10-20 mg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Target dose

050100u

Draw to

— units

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How it works

Pancragen modulates gene expression in pancreatic beta-cells and exocrine cells, supporting insulin gene transcription, glucose-sensing pathways, and pancreatic tissue maintenance at the epigenetic level.

What to expect

Early

Days 1–7

Days 1-10: Gene changes initiated.

Mid

Weeks 2–4

Weeks 2-8: Pancreatic gene programs established.

Later

Weeks 4–12

Months: Sustained pancreatic tissue support.

Evidence

HumanPresent

AnimalPresent

In-vitroPresent

2010Study of biological activity of Lys-Glu-Asp-Trp-NH2 endogenous tetrapeptide · Khavinson VKh et al, Bulletin of Experimental Biology and Medicine ↗peer reviewed

2021Peptide Regulation of Gene Expression: A Systematic Review · Khavinson V et al, Molecules ↗review

2013Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results · Kuznik BI et al, Advances in Gerontology ↗review

The honest take

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Beta-cell preservation

Bioregulatory mechanism targeting pancreatic tissue gene expression. May support insulin secretion pathways.

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

ALL (syringe)PIN ALONE.

GHK-CuCopper degrades bioregulators.

MetforminPancragen targets pancreatic function. Monitor blood glucose closely if on diabetes medications.

GLP-1 agonistsBoth affect pancreatic function. Monitor blood sugar.

Side effects & safety

Commonly reported

Very well tolerated

Less common & notes

Monitor blood glucose if on diabetes medications.
Excellent safety profile.

Pharmacokinetics

Illustrative plasma concentration · 24 h

Half-life

0.5h

Peak · Tmax

0.05h

Elimination

2.5h

Activity

24-48 hours (gene expression changes persist beyond peptide clearance)

Storage. Standard BAC water 2-8C. 21-28 days.

Regulatory status

Not FDA-approved. Research peptide.

Put it to work

Calculate, log & track

Open Pancragen straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Pancragen in the app →

Go deeper

The guide & community

The complete Pancragen walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

Open in app Community