Bioregulators Khavinson bioregulator pentapeptideNot FDA-approved · research compound

Pancragen

Pancragen (Khavinson)

Evidence: Studied in humans. Example dose: finalize with a provider. Not a fact-check stamp.

25-50 mcg daily SubQ 10 day course, 2-3 cycles per year

10-20 mg Oral Daily

Pancreatic tissue regulatorBeta-cell function modulator

Pancragen (Lys-Glu-Asp-Trp-Pro) is a Khavinson bioregulator pentapeptide targeting pancreatic tissue gene expression. It supports beta-cell function, insulin secretion pathways, and pancreatic tissue maintenance. Relevant for age-related pancreatic decline and metabolic health optimization.

Quick Start

Route

SubQ injection

Start low

25-50 mcg SubQ

Frequency

10 day course, 2-3 cycles per year

Timing

No fasting required

Starting dose. 25-50 mcg — Daily

SubQ injection, any time of day. 10-20 day courses, 2-3 cycles per year with 4-6 months between courses (Khavinson protocol). Pin alone or with other bioregulators only.

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Conservative start

25-50 mcg daily · SubQ injection · 10 day course, 2-3 cycles per year

conservative starter

25-50 mcg daily

10 day course, 2-3 cycles per year

Standard

Pancreatic Islet Support (Oral capsule)

10-20 mg · Oral · Daily

human study · Korkushko OV, Khavinson VK, Shatilo VB, et al. Prospects of using pancragen for correction of metabolic disorders in elderly people. Bull Exp Biol Med. 2011;151(4):454-456. PMID 22448364.

Often stacked with lifestyle interventions for glycemic control. This is the ORAL capsule dose and is not an injection dose. Oral peptide absorption is poor, so this figure is far higher than the injectable protocol on purpose. Do not inject this amount.

10-20 mg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Vials in this mix

Syringe size

Target dose

050100u

Draw to

— units

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I will split this dose across more than one syringe

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How it works

Pancragen modulates gene expression in pancreatic beta-cells and exocrine cells, supporting insulin gene transcription, glucose-sensing pathways, and pancreatic tissue maintenance at the epigenetic level.

What to expect

Early

Days 1–7

Days 1-10: Gene changes initiated.

Mid

Weeks 2–4

Weeks 2-8: Pancreatic gene programs established.

Later

Weeks 4–12

Months: Sustained pancreatic tissue support.

Evidence

HumanPresent

AnimalPresent

In-vitroPresent

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

Expression of differentiation markers was found to be reduced during ageing of pancreatic cells.

Expression of differentiation markers was found to be reduced during ageing of pancreatic cells.

Effects of pancragen on the differentiation of pancreatic cells during their ageing. Bulletin of experimental biology and medicine · 2013 · PMID 23486591

Evidence scope. In-vitro aging pancreatic-cell model; not evidence for subcutaneous human administration.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: 25-50 mcg daily via SubQ injection, 10 day course, 2-3 cycles per year. No checked live PubMed abstract supported this complete molecule/formulation/route/dose/frequency combination.

Primary safety claim: Very well tolerated. No checked live abstract directly established this as the primary concern for the card's exact formulation and regimen.

The honest take

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Beta-cell preservation

Bioregulatory mechanism targeting pancreatic tissue gene expression. May support insulin secretion pathways.

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

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Pin alone. Pancragen must not share a syringe with anything else, whatever the pharmacology says. PIN ALONE.

Keep separate

GHK-CuCopper degrades bioregulators.

MetforminPancragen targets pancreatic function. Monitor blood glucose closely if on diabetes medications.

GLP-1 agonistsBoth affect pancreatic function. Monitor blood sugar.

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

Side effects & safety

Commonly reported

Very well tolerated

Less common & notes

Monitor blood glucose if on diabetes medications.
Excellent safety profile.

Pharmacokinetics

Illustrative plasma concentration · 2.0 h

Half-life

0.5h

Peak · Tmax

0.05h

Elimination

2.5h

Bioavailability

~100%

SubQ

Duration of action

24-48 hours

Gene expression changes persist beyond peptide clearance

Clearance

Enzymatic degradation (peptidases)

Storage. Standard BAC water 2-8C. 21-28 days.

Regulatory status

Not FDA-approved. Research peptide.

Put it to work

Calculate, log & track

Open Pancragen straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Pancragen in the app →

Go deeper

The guide & community

The complete Pancragen walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

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