OnePin Peptide Library · Hormonal
Kisspeptin
Kisspeptin-10 · KP-10 · Metastin
Kisspeptin is a peptide encoded by the KISS1 gene that acts as the master upstream regulator of the reproductive hormone axis. It stimulates GnRH (gonadotropin-releasing hormone) neurons in the hypothalamus, which in turn triggers LH and FSH release from the pituitary, driving testosterone production and spermatogenesis. Kisspeptin acts upstream of GnRH, making it the most physiologically natural way to stimulate the entire HPG (hypothalamic-pituitary-gonadal) axis.
Per physician direction. Timing depends on clinical indication.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Kisspeptin binds to the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering GnRH pulsatile release. This cascade stimulates pituitary LH and FSH secretion, which drives testicular testosterone production and spermatogenesis. Unlike HCG (which bypasses the hypothalamus/pituitary by directly stimulating Leydig cells), Kisspeptin preserves the entire HPG feedback loop.
Kisspeptin binds to the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering GnRH pulsatile release. This cascade stimulates pituitary LH and FSH secretion, which drives testicular testosterone production and spermatogenesis. Unlike HCG (which bypasses the hypothalamus/pituitary by directly stimulating Leydig cells), Kisspeptin preserves the entire HPG feedback loop.
What to expect
Hours: LH elevation detectable.
Days-weeks: Testosterone response.
Ongoing: HPG axis modulation.
Evidence
The honest take
Most physiological HPG stimulation
Confirmed. Kisspeptin is the most upstream activator of the reproductive axis, preserving all natural feedback mechanisms.
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Side effects & safety
Commonly reported
- Injection site reaction
- Warmth or flushing
Less common & notes
- Limited adverse event data.
- Endogenous peptide suggesting good tolerability.
Pharmacokinetics
Storage. Standard BAC water 2-8C. 28 days.
Regulatory status
Not FDA-approved for routine use. Used in IVF research. Available as research peptide.
Put it to work
Calculate, log & track
Open Kisspeptin straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Kisspeptin in the app →Go deeper
The guide & community
The complete Kisspeptin walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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