OnePin Peptide Library · Hormonal
HMG
Human Menopausal Gonadotropin · Menotropin
HMG (Human Menopausal Gonadotropin) is a mixture of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women, who excrete high levels of these gonadotropins due to absent ovarian negative feedback. FDA-approved formulations include Menopur (Ferring) and historic Pergonal. Standard composition: 75 IU FSH + 75 IU LH per ampoule, with FSH:LH ratio approximately 1:1.
Per fertility specialist (cycle protocol) or endocrinologist (TRT/PCT). Reconstitute Menopur per label. Refrigerate.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
HMG provides exogenous gonadotropin stimulation to the gonads:
FSH Component
In females, FSH stimulates ovarian follicular development and granulosa cell estrogen production. In males, FSH stimulates Sertoli cells to support spermatogenesis - critical for fertility preservation during exogenous testosterone use.
LH Component
In females, LH triggers ovulation when sufficient follicular maturation has occurred and supports luteal phase progesterone. In males, LH stimulates testicular Leydig cell testosterone production - the primary mechanism for HCG/HMG use in maintaining testicular function during TRT.
Distinct From HCG
HCG (human chorionic gonadotropin) acts primarily as an LH-mimic with very long half-life (~24-30 hours) - drives Leydig testosterone production but provides minimal FSH support. HMG provides BOTH FSH and LH - more complete gonadotropin replacement, particularly relevant for spermatogenesis recovery in PCT contexts.
Pulse Pattern
HMG provides relatively sustained gonadotropin elevation rather than the pulsatile release of endogenous FSH/LH. This works clinically but may suboptimally mimic native physiology in some contexts.
Female Hyperstimulation Risk
In ovulation induction / IVF, excessive HMG response produces ovarian hyperstimulation syndrome (OHSS) - the dominant safety concern. Careful dose titration and monitoring with estradiol and ultrasound mitigate.
Male Use Specifics
TRT/PCT use targets testicular function maintenance. Combined with HCG (LH mimic) sometimes used for both rapid Leydig response (HCG) and sustained Sertoli/spermatogenesis support (HMG/FSH).
What to expect
Female fertility: ovarian response visible on ultrasound within 5-7 days. Male: gradual gonadotropin response over 2-4 weeks.
Female: ovulation typically 10-14 days into cycle. Male: testicular size and testosterone improvements visible 4-8 weeks.
Long-term TRT adjunct: sustained testicular function maintenance with continued dosing.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Keep separate
Side effects & safety
Commonly reported
- Injection site reaction (mild)
- Mild headache
- Abdominal bloating (female - early ovarian response)
- Flushing
Less common & notes
- Ovarian hyperstimulation syndrome (OHSS) in females - dominant safety concern in fertility cycles.
- Severe form (ascites, electrolyte disturbance, thromboembolism risk) requires hospitalization.
- Mild OHSS resolves with cycle.
- Gynecomastia in males if excessive aromatization.
- Allergic reactions rare but documented (urinary-derived protein source).
- Multiple pregnancy in fertility cycles (twins/triplets) - manageable risk with monitoring.
- Long-term use of urinary-derived gonadotropins generally well-tolerated.
Pharmacokinetics
Storage. Lyophilized: refrigerate. Reconstituted: refrigerate, use within 28 days per Menopur label. Light-sensitive.
Regulatory status
FDA-approved as Menopur (Ferring) and historically Pergonal (Serono) for: female ovulation induction, IVF stimulation, male hypogonadotropic hypogonadism. Off-label use for TRT adjunct and PCT requires endocrinologist supervision. WADA prohibited under class S2 (peptide hormones) both in and out of competition - relevant for athletes.
Put it to work
Calculate, log & track
Open HMG straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open HMG in the app →Go deeper
The guide & community
The complete HMG walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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