library.onepin.app/ghrp-2 Peptide Education Library

Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Growth Hormone

Growth Hormone Synthetic hexapeptide Not FDA-approved · investigational

GHRP-2

Pralmorelin · GHRP2

Synthetic hexapeptideGhrelin receptor (GHS-R1a) agonistGrowth hormone releasing peptideApproved in Japan (Pralmorelin)

GHRP-2 (Growth Hormone Releasing Peptide-2, Pralmorelin) is a synthetic hexapeptide ghrelin receptor agonist that stimulates GH release from the anterior pituitary. It is more potent than Ipamorelin but less selective, significantly increasing appetite (via ghrelin pathway), mildly elevating cortisol and prolactin at higher doses. GHRP-2 was one of the first GHRPs developed and has been approved in Japan (Pralmorelin) for GH deficiency diagnosis. It produces robust GH pulses but the appetite stimulation and cortisol/prolactin effects make Ipamorelin preferred in most modern protocols.

Quick Start

Route

SubQ injection

Start low

100-200 mcg

Frequency

1-3 times daily

Timing

Fasted. Potent appetite stimulation.

Fasted 2+ hours. Bedtime preferred. Can split into 2-3 daily doses, each fasted. Stronger hunger signal than Ipamorelin.

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Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Quick Start

Conservative start

100-200 mcg · SubQ injection · 1-3 times daily

Lowest starting point. Hold about a week to assess tolerance before stepping up.

100-200 mcg

1-3 times daily

Standard

Standard GH Release

100-300 mcg · SubQ · 2x Daily

human study · Laferrere et al. 2005 (J Clin Endocrinol Metab 90(2):611-614, PMID 15699539)

100-300 mcg

2x Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Target dose

050100u

Draw to

— units

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How it works

GHRP-2 binds GHS-R1a (ghrelin receptor) with higher affinity than Ipamorelin, producing stronger GH release. Unlike Ipamorelin, it also activates hypothalamic appetite centers (ghrelin-mediated hunger) and mildly stimulates ACTH/cortisol and prolactin release at standard doses. Best paired with a GHRH analog for synergistic dual-pathway stimulation.

What to expect

Early

Days 1–7

Days 1-7: Strong hunger. Sleep improvements.

Mid

Weeks 2–4

Weeks 2-6: Body composition changes beginning.

Later

Weeks 4–12

Weeks 6-16: Full effects with GHRH analog.

Evidence

HumanPresent

AnimalStrong

In-vitroPresent

1997Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature · Pihoker C, Kearns GL, French D, Bowers CY, Journal of Endocrinology ↗trial registry

2005Growth Hormone Releasing Peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men · Laferrere B, Abraham C, Russell CD, Bowers CY, Journal of Clinical Endocrinology & Metabolism ↗trial registry

1995Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature · Mericq V, Cassorla F, Salazar T, et al, Journal of Clinical Endocrinology & Metabolism ↗peer reviewed

2018The Safety and Efficacy of Growth Hormone Secretagogues · Sigalos JT, Pastuszak AW, Sexual Medicine Reviews ↗review

The honest take

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Stronger than Ipamorelin

Confirmed. Higher GH release per dose but at cost of appetite stimulation and cortisol/prolactin elevation.

Appetite stimulation

Confirmed via ghrelin pathway. Therapeutic advantage in wasting conditions, disadvantage in weight management.

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Safe & synergistic

BPC-157BPC GH receptor upregulation

VIPNo conflict

CJC-1295 no DACGHRP + GHRH dual pathway synergy.

SermorelinGHRP + GHRH synergy.

Keep separate

TesamorelinTesamorelin paired with Ipamorelin in standard protocols. GHRP-2 would replace Ipa, not stack.

CJC-1295 with DACDAC maleimide.

Side effects & safety

Commonly reported

Strong hunger/appetite increase
Water retention
Mild cortisol elevation
Mild prolactin elevation

Less common & notes

Anxiety or sleep disruption from cortisol effects at higher doses.
Prolactin-related effects rare at standard doses.

Pharmacokinetics

Illustrative plasma concentration · 24 h

Half-life

0.5h

Peak · Tmax

0.25h

Elimination

2.5h

Activity

4-6 hours (GH pulse lasts 2-3 hours; downstream IGF-1 elevation persists longer)

Storage. Standard BAC water 2-8C. 28 days.

Regulatory status

Approved in Japan as Pralmorelin. Not FDA-approved. WADA prohibited under S2.

Put it to work

Calculate, log & track

Open GHRP-2 straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open GHRP-2 in the app →

Go deeper

The guide & community

The complete GHRP-2 walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

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