OnePin Peptide Library · Growth Hormone
Sermorelin
Sermorelin Acetate · GHRH (1-29)
Sermorelin is a synthetic 29-amino acid peptide corresponding to the first 29 amino acids of endogenous GHRH (the biologically active fragment). It was the first GHRH analog developed and was previously FDA-approved as Geref for diagnostic use and pediatric growth hormone deficiency. While it has been largely superseded by Tesamorelin and CJC-1295 no DAC in modern protocols, Sermorelin remains available through compounding pharmacies and is still used in GH optimization protocols, particularly paired with GHRPs.
Bedtime dosing on empty stomach. Same fasting rules as Ipamorelin (2+ hours). Amplifies natural nighttime GH pulse.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Sermorelin binds GHRH receptors on pituitary somatotrophs, identical mechanism to Tesamorelin and CJC-1295 no DAC. It stimulates pulsatile GH release through cAMP/PKA signaling. As the native GHRH(1-29) sequence without additional modifications, it is more susceptible to DPP-IV degradation than modified analogs, resulting in a shorter effective window.
Sermorelin binds GHRH receptors on pituitary somatotrophs, identical mechanism to Tesamorelin and CJC-1295 no DAC. It stimulates pulsatile GH release through cAMP/PKA signaling. As the native GHRH(1-29) sequence without additional modifications, it is more susceptible to DPP-IV degradation than modified analogs, resulting in a shorter effective window.
What to expect
Days 1-7: Sleep improvements.
Weeks 2-6: Recovery and body composition changes beginning.
Weeks 6-16: Full body composition effects.
Evidence
The honest take
Previously FDA-approved
Geref was FDA-approved for GH deficiency diagnosis and pediatric treatment. Withdrawn for commercial reasons, not safety.
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Side effects & safety
Commonly reported
- Injection site reaction
- Mild water retention
- Flushing
Less common & notes
- Well-characterized safety from FDA approval history.
- Similar GH-related side effects as Tesamorelin.
Pharmacokinetics
Storage. Standard BAC water 2-8C. 28 days stability.
Regulatory status
Previously FDA-approved as Geref (withdrawn). Available through compounding. WADA prohibited under S2.
Put it to work
Calculate, log & track
Open Sermorelin straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Sermorelin in the app →Go deeper
The guide & community
The complete Sermorelin walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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