OnePin Peptide Library · Growth Hormone
CJC-1295 with DAC
CJC-1295 DAC · CJC1295 DAC · CJC-DAC
CJC-1295 with DAC (Drug Affinity Complex) is a synthetic GHRH analog with a maleimide-based linker that covalently binds to serum albumin via the Cys34 thiol residue. This albumin binding extends the half-life from approximately 30 minutes (no DAC) to 6-8 days, providing sustained baseline GH elevation from a single weekly injection. The DAC maleimide group is the reason this compound must be pinned alone: maleimide reacts with thiol (sulfhydryl) groups found in cysteine residues of other peptides, potentially degrading co-administered compounds in the syringe. CJC-1295 with DAC provides continuous GHRH receptor stimulation rather than pulsatile, which is pharmacologically distinct from CJC no DAC and Tesamorelin.
Weekly injection. Any time of day. No fasting required (long-acting, no acute GH pulse). Pin alone always.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
CJC-1295 with DAC binds GHRH receptors identically to CJC no DAC, activating cAMP/PKA signaling for GH release. The DAC maleimide linker covalently binds albumin Cys34, creating a circulating depot that slowly releases active peptide over 6-8 days. This produces sustained GH elevation rather than acute pulses. When combined with Ipamorelin (which provides acute pulses on top of the sustained baseline), the result is elevated baseline GH with superimposed pulsatile peaks. The maleimide chemistry that enables albumin binding also makes CJC-DAC reactive with free thiol groups on other peptides, which is why it must be pinned alone.
CJC-1295 with DAC binds GHRH receptors identically to CJC no DAC, activating cAMP/PKA signaling for GH release. The DAC maleimide linker covalently binds albumin Cys34, creating a circulating depot that slowly releases active peptide over 6-8 days. This produces sustained GH elevation rather than acute pulses. When combined with Ipamorelin (which provides acute pulses on top of the sustained baseline), the result is elevated baseline GH with superimposed pulsatile peaks. The maleimide chemistry that enables albumin binding also makes CJC-DAC reactive with free thiol groups on other peptides, which is why it must be pinned alone.
What to expect
Week 1-2: GH and IGF-1 elevation begins. Sleep improvements. Steady-state reached by second injection.
Weeks 4-8: Body composition changes. Recovery improvements. Lab should show elevated IGF-1.
Weeks 8-12: Significant body composition results when paired with Ipamorelin, diet, and training.
Evidence
The honest take
Weekly convenience
Confirmed. 6-8 day half-life allows true once-weekly dosing. Major practical advantage over daily Tesamorelin or CJC no DAC.
Pulsatile GH release (CJC no DAC, Tesamorelin) more closely mimics natural physiology. Sustained (DAC) provides higher total GH exposure. Which is superior for body composition is debated. Combining DAC (baseline) + Ipamorelin (pulses) attempts to capture both.
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Side effects & safety
Commonly reported
- Water retention
- Joint stiffness
- Injection site reaction
- Numbness/tingling in hands
Less common & notes
- Continuous GH elevation may carry different risk profile than pulsatile.
- Monitor glucose homeostasis closely.
- Potential for greater IGF-1 elevation than pulsatile protocols.
- Contraindicated in active malignancy.
Pharmacokinetics
Storage. Maleimide DAC linker susceptible to hydrolysis in solution. Use within 21-28 days after reconstitution. Refrigerate 2-8C. Protect from light. Unreconstituted powder stable frozen for extended periods.
Regulatory status
Not FDA-approved. WADA prohibited under S2. Available through compounding and research channels.
Put it to work
Calculate, log & track
Open CJC-1295 with DAC straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open CJC-1295 with DAC in the app →Go deeper
The guide & community
The complete CJC-1295 with DAC walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
Join the community ↗