library.onepin.app/hexarelin Peptide Education Library

Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Growth Hormone

Growth Hormone Synthetic hexapeptide

Hexarelin

Hex

Synthetic hexapeptideMost potent GHRPGhrelin receptor agonistCardioprotective peptide

Hexarelin (Examorelin) is a synthetic hexapeptide and the most potent GHRP in terms of raw GH release per dose. It activates the ghrelin receptor (GHS-R1a) with the highest efficacy of the GHRP family but also desensitizes the receptor fastest, requiring shorter cycle lengths (4-8 weeks) compared to Ipamorelin (8-16 weeks). Hexarelin produces significant cortisol and prolactin elevation and moderate appetite stimulation. It also has unique cardioprotective properties independent of GH release, acting directly on cardiac tissue.

Quick Start

Route

SubQ injection

Start low

100-200 mcg

Frequency

1-2 times daily, shorter cycles

Timing

Fasted.

Fasted 2+ hours. Bedtime preferred. Do not use longer than 8 weeks continuously (desensitization).

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Quick Start

Conservative start

100-200 mcg · SubQ injection · 1-2 times daily, shorter cycles

Lowest starting point. Hold about a week to assess tolerance before stepping up.

100-200 mcg

1-2 times daily, shorter cycles

Expert

Short Cycle (Max Pulse)

100 mcg · SubQ · Daily

human study · Ghigo et al. 1994 (J Clin Endocrinol Metab 78(3):693-698, PMID 8126144)

100 mcg

Daily

Reconstitution CalculatorU-100

Vial strength

BAC water

Target dose

050100u

Draw to

— units

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How it works

Hexarelin activates GHS-R1a with the highest efficacy of any GHRP. Also has direct cardiac effects independent of GH, including cardioprotection via scavenger receptor CD36 binding and activation of protective signaling in cardiomyocytes. Desensitizes GHS-R1a faster than other GHRPs due to strong receptor activation, requiring cycling.

What to expect

Early

Days 1–7

Days 1-7: Strong GH response. Hunger and flushing.

Mid

Weeks 2–4

Weeks 2-4: Peak effects.

Later

Weeks 4–12

Weeks 4-8: Desensitization begins. Cycle off.

Evidence

HumanModerate

AnimalStrong

In-vitroPresent

2002Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery · Broglio F, Guarracino F, Benso A, et al, European Journal of Pharmacology ↗peer reviewed

1999Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans · Bisi G, Podio V, Valetto MR, et al, Journal of Endocrinological Investigation ↗peer reviewed

1999Cardiac effects of hexarelin in hypopituitary adults · Locatelli V, Rossoni G, Schweiger F, et al, European Journal of Pharmacology ↗peer reviewed

2000The growth hormone secretagogue hexarelin improves cardiac function in rats after experimental myocardial infarction · Tivesten A, Bollano E, Caidahl K, et al, Endocrinology ↗peer reviewed

The honest take

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Most potent GHRP

Confirmed. Highest GH release per dose. Trade-off is faster desensitization.

Cardioprotective

Unique among GHRPs. Direct cardiac effects via CD36 scavenger receptor independent of GH. Published human cardiac data.

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Safe & synergistic

BPC-157Non-overlapping

VIPNo conflict

CJC-1295 no DACGHRP + GHRH synergy. Maximum GH output combination.

SermorelinGHRP + GHRH synergy.

Keep separate

TesamorelinStandard protocols pair Tesa with Ipa.

CJC-1295 with DACDAC maleimide.

Side effects & safety

Commonly reported

Moderate hunger
Cortisol and prolactin elevation
Water retention
Flushing

Less common & notes

Faster receptor desensitization limits cycle length.
Prolactin elevation higher than Ipamorelin.
Monitor for gynecomastia symptoms at higher doses.

Pharmacokinetics

Illustrative plasma concentration · 24 h

Half-life

Peak · Tmax

0.5h

Elimination

Activity

4-6 hours (GH pulse)

Storage. Standard BAC water 2-8C. 28 days.

Regulatory status

Approved for diagnostic use in some countries. WADA prohibited under S2.

Put it to work

Calculate, log & track

Open Hexarelin straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Hexarelin in the app →

Go deeper

The guide & community

The complete Hexarelin walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗

Open in app Community