OnePin Peptide Library · Metabolic
SLU-PP-332
SLU-PP332
SLU-PP-332 is a synthetic small molecule that acts as a pan-ERR (estrogen-related receptor) agonist, activating ERRalpha, ERRbeta, and ERRgamma. It is classified as an exercise mimetic - a compound that can replicate some of the molecular effects of physical exercise without actual physical activity. Despite the name, estrogen-related receptors do NOT bind estrogen and have no estrogenic activity.,ERRalpha activation by SLU-PP-332 upregulates PGC-1alpha, a master regulator of mitochondrial biogenesis and fatty acid oxidation. In animal studies, it increased exercise endurance by 20-30%, promoted conversion of glycolytic muscle fibers (type IIb) to oxidative fibers (type IIa), and activated an acute aerobic exercise gene program including Ddit4. These effects were mediated specifically through ERRalpha.,SLU-PP-332 is a research compound with NO human clinical trials. All dosing protocols in the biohacking community are extrapolated from rodent data. It is available as both lyophilized vials for SubQ injection and oral capsules. The compound was developed at Saint Louis University (hence SLU in the name) and first described in published research around 2011-2012.
No human dosing protocol exists. Animal exposures must not be scaled into a human dose.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Activates all three estrogen-related receptors (ERRalpha EC50=98nM, ERRbeta EC50=230nM, ERRgamma EC50=430nM) with 4.4x selectivity for ERRalpha over ERRgamma. Despite the name, ERRs are orphan nuclear receptors with NO estrogenic activity.,ERRalpha activation upregulates PGC-1alpha, the master regulator of mitochondrial biogenesis, driving increased mitochondrial density, enhanced fatty acid oxidation, and improved oxidative phosphorylation capacity in skeletal muscle.,Induces conversion of glycolytic type IIb muscle fibers to oxidative type IIa fibers, mimicking the fiber-type shift seen with endurance training. Also activates the Ddit4 gene program associated with acute aerobic exercise.
Activates all three estrogen-related receptors (ERRalpha EC50=98nM, ERRbeta EC50=230nM, ERRgamma EC50=430nM) with 4.4x selectivity for ERRalpha over ERRgamma. Despite the name, ERRs are orphan nuclear receptors with NO estrogenic activity.,ERRalpha activation upregulates PGC-1alpha, the master regulator of mitochondrial biogenesis, driving increased mitochondrial density, enhanced fatty acid oxidation, and improved oxidative phosphorylation capacity in skeletal muscle.,Induces conversion of glycolytic type IIb muscle fibers to oxidative type IIa fibers, mimicking the fiber-type shift seen with endurance training. Also activates the Ddit4 gene program associated with acute aerobic exercise.
What to expect
Days 1-7: Subtle metabolic effects beginning. Possible mild increase in energy and exercise tolerance.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Lyophilized powder: -20C, dry, protected from light. Reconstituted: 2-8C (refrigerated), use within 14 days. Oral capsules: room temperature, cool and dry.
Regulatory status
Preclinical / research-use-only. No human dose, PK, or safety data exists. Research chemical. Not FDA-approved for any indication. No IND filed. Not scheduled or controlled. Available from research chemical and peptide vendors as lyophilized powder or oral capsules. CAS: 303760-60-3.
Put it to work
Calculate, log & track
Open SLU-PP-332 straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
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The guide & community
The complete SLU-PP-332 walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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