library.onepin.app/lipo-c-mic Peptide Education Library
Education only, not medical advice 21+ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Metabolic

Metabolic Peptide Not FDA-approved · investigational

Lipo-C/MIC

MIC · Lipo-MIC · Methionine Inositol Choline · Lipotropic

Lipo-C/MIC is a lipotropic injection blend containing methionine, inositol, and choline (the 'MIC' components) along with cyanocobalamin (vitamin B12) and often L-carnitine. These compounds are classified as lipotropic agents - substances that promote the breakdown and metabolism of fat in the body. The injection is widely used in weight management clinics and integrative medicine practices as an adjunct to diet and exercise programs.,Each component serves a specific role: methionine is an essential amino acid that acts as a lipotropic agent and methyl donor; inositol is a carbocyclic sugar that participates in fat metabolism and insulin signaling; choline is essential for liver function, fat transport, and cell membrane integrity; and B12 supports energy metabolism and red blood cell formation. Together, they are intended to support hepatic fat processing and overall metabolic function.,Lipo-C/MIC injections are compounded preparations, not FDA-approved as a specific drug product. The individual components are well-characterized nutrients with established safety profiles. While these injections are widely used in clinical practice for weight management support, high-quality randomized controlled trials specifically evaluating the MIC combination injection for weight loss are limited. Efficacy is primarily supported by the known biochemical roles of the individual components and clinical observation.

Quick Start
Route
Intramuscular (IM)
Start low
1mL
Frequency
weekly
Timing
No specific requirement

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
1mL · Intramuscular (IM) · weekly
Lowest starting point. Hold about a week to assess tolerance before stepping up.
1mL
weekly
Standard
Lipotropic Injection
1 mL · IM · 2x Weekly
anecdotal · community
1 mL
2x Weekly
01

How it works

Methionine, inositol, and choline act as lipotropic agents that promote hepatic fat metabolism: methionine provides methyl groups for metabolic reactions, inositol aids fat transport and insulin signaling, and choline is required for VLDL synthesis and fat export from the liver.,Vitamin B12 (cyanocobalamin) serves as a cofactor for methionine synthase and methylmalonyl-CoA mutase, supporting energy metabolism, methylation reactions, and red blood cell production.,L-carnitine (when included) facilitates transport of long-chain fatty acids into mitochondria for beta-oxidation, directly supporting fat utilization for energy.

Methionine, inositol, and choline act as lipotropic agents that promote hepatic fat metabolism: methionine provides methyl groups for metabolic reactions, inositol aids fat transport and insulin signaling, and choline is required for VLDL synthesis and fat export from the liver.,Vitamin B12 (cyanocobalamin) serves as a cofactor for methionine synthase and methylmalonyl-CoA mutase, supporting energy metabolism, methylation reactions, and red blood cell production.,L-carnitine (when included) facilitates transport of long-chain fatty acids into mitochondria for beta-oxidation, directly supporting fat utilization for energy.

02

What to expect

Early
Days 1–7

Days 1-7: Energy boost from B12. Mild improvement in alertness and mood. Fat metabolism effects building.

03

Evidence

HumanStrong
AnimalPresent
In-vitroPresent
2013Metabolic and structural effects of phosphatidylcholine and deoxycholate injections on subcutaneous fat: a randomized, controlled trial · Salti G et al, Aesthetic Surgery Journal ↗peer reviewed
2018Injection Lipolysis: A Systematic Review of Literature and Our Experience with a Combination of Phosphatidylcholine and Deoxycholate over a Period of 14 Years in 1269 Patients · Thomas MK et al, Journal of Cutaneous and Aesthetic Surgery ↗review
2006Clinical experience and safety using phosphatidylcholine injections for the localized reduction of subcutaneous fat: a multicentre, retrospective UK study · Duncan DI, Hasengschwandtner F, Journal of Cosmetic and Laser Therapy ↗peer reviewed
2008Fat reduction using phosphatidylcholine/sodium deoxycholate injections: standard of practice · Duncan D et al, Aesthetic Plastic Surgery ↗review
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Safe & synergistic

Injectable B-ComplexMIC already contains B12 - additional B-complex is compatible but may be redundant for B12 specifically. Administer separately.
Testosterone CypionateNo pharmacological conflict - lipotropic support during hormone optimization
MelatoninNo interaction - different systems entirely
L-Carnitine InjectableComplementary lipotropic pathways - MIC supports hepatic fat processing while L-carnitine shuttles fatty acids into mitochondria for oxidation

Keep separate

GHK-CuMethionine in MIC can interfere with copper-peptide stability - never mix in same syringe and consider spacing doses
GHKMethionine may compete with GHK for copper binding - avoid mixing or concurrent administration
Any compound in same syringeLipo-C/MIC is a pre-mixed multi-component solution - always administer alone in its own syringe
05

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
Varies by component: B12 ~6 days (tissue retention), methionine ~2-3 hours, choline ~hours, inositol ~hours
Peak · Tmax
~1-2 hours (IM). Variable by component.
Elimination
Variable by component. Methionine/choline/inositol cleared within ~12-24 hours. B12 retained in tissues for weeks.
Activity
24-72 hours (metabolic effects; B12 tissue effects persist for days to weeks)

Storage. Store refrigerated at 2-8C. Protect from light. B12 is light-sensitive.

06

Regulatory status

Compounded preparation - not FDA-approved as a specific drug product. Individual components (B12, methionine, inositol, choline) are established nutrients. Available through compounding pharmacies by prescription. Typically administered alone - do not mix with other injectable compounds.

Put it to work

Calculate, log & track

Open Lipo-C/MIC straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Lipo-C/MIC in the app →

Go deeper

The guide & community

The complete Lipo-C/MIC walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
Open in app Community