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OnePin Peptide Library · Cognitive & Mood

Cognitive & Mood Ginkgo biloba leaf extract (EGb 761)

Ginkgo Biloba

Ginkgo · EGb 761

Ginkgo biloba leaf extract (EGb 761)Cognitive / Cerebrovascular SupportAntiplatelet BotanicalDietary Supplement / EU Pharmaceutical

Ginkgo Biloba (extract from leaves of the maidenhair tree) is one of the most-researched cognitive supplements. Standardized extract EGb 761 (24% flavone glycosides + 6% terpene lactones) is the most-studied form. Active compounds: ginkgolides (terpene lactones - PAF antagonists), bilobalide (terpene lactone), and flavonoid glycosides (antioxidants).

Quick Start
Route
Oral capsule or tablet
Start low
120-240mg daily standardized extract
Frequency
1-3x daily
Timing
With food

Divided doses preferred.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
120-240mg daily standardized extract · Oral capsule or tablet · 1-3x daily
conservative starter
Lowest starting point. Hold about a week to assess tolerance before stepping up.
120-240mg daily standardized extract
1-3x daily
Standard
Cerebral Blood Flow
120-240 mg · Oral · Daily
human clinical trial · Kennedy et al. 2000 (Psychopharmacology)
Standardized extract (EGb 761) is recommended. Do not exceed 240mg daily.
120-240 mg
Daily
◆
01

How it works

Ginkgo's bioactives have multiple effects:

Ginkgolides

Platelet activating factor (PAF) antagonists. Reduce platelet aggregation - basis of antiplatelet effect AND cerebrovascular benefit.

Bilobalide

Neuroprotective in ischemia models; modulates GABAergic transmission.

Flavonoid Glycosides

Antioxidant and capillary-stabilizing effects.

Cerebrovascular

Improved cerebral blood flow via vasodilation and antiplatelet action.

Cognitive

Modest improvements in memory, attention, and processing speed in older adults with cognitive complaints.

02

What to expect

Early
Days 1–7

Days 1-14: minimal subjective change.

Mid
Weeks 2–4

Weeks 4-8: peak cognitive effects.

Later
Weeks 4–12

Long-term continuous use OK.

03

Evidence

HumanStrong
AnimalStrong
In-vitroPresent
2009Ginkgo biloba for cognitive impairment and dementia · Birks J, Grimley Evans J, Cochrane Database ↗review
2002Ginkgo biloba special extract EGb 761 in cerebral insufficiency · DeFeudis FV, Pharmacological Research ↗review
2008Ginkgo biloba and bleeding risk · Bone KM, Phytotherapy Research ↗review
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

05

Side effects & safety

Commonly reported

  • Mild GI
  • Headache (early dosing)
  • Dizziness rare

Less common & notes

  • BLEEDING RISK - especially with anticoagulants/NSAIDs.
  • Allergic reactions rare.
  • Pre-surgical discontinuation 2 weeks recommended.
06

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
Ginkgolides ~3-7 hours
Peak · Tmax
1-3 hours
Elimination
Hours plasma; cognitive effects accumulate over weeks
Activity
Daily dosing for sustained effects

Storage. Capsule. Cool dry location.

07

Regulatory status

Dietary supplement (US, DSHEA). Pharmaceutical (EGb 761) in EU/Germany.

Put it to work

Calculate, log & track

Open Ginkgo Biloba straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Ginkgo Biloba in the app →

Go deeper

The guide & community

The complete Ginkgo Biloba walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
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