Cognitive & Mood Dietary supplementCentella asiatica (Ayurvedic / TCM Herb)

Gotu Kola

Centella asiatica

Evidence: Studied in humans. Example dose: finalize with a provider. Not a fact-check stamp.

500mg-1g oral daily Topical 1-2x daily oral; topical as formulated

500-1000 mg Oral Daily

Cognitive / Venous Insufficiency / Wound HealingTriterpenoid (TECA) Botanical

Gotu Kola (Centella asiatica) is an Ayurvedic and TCM herb used for centuries for cognitive support, wound healing, and venous insufficiency. Active compounds: triterpenoids (asiaticoside, asiatic acid, madecassic acid, madecassoside) - the 'TECA' (Titrated Extract of Centella Asiatica) standardized form is the most-researched.

Quick Start

Route

Oral capsule, powder, or topical

Start low

500mg-1g Topical

Frequency

1-2x daily oral; topical as formulated

Timing

With food

Independent.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Conservative start

500mg-1g oral daily · Oral capsule, powder, or topical · 1-2x daily oral; topical as formulated

conservative starter

500mg-1g oral daily

1-2x daily oral; topical as formulated

Standard

Neuroprotection & Circulation

500-1000 mg · Oral · Daily

human clinical trial · Wattanathorn et al. 2008 (J Ethnopharmacol)

Highly synergistic with Bacopa for long-term cognitive and anxiolytic benefits.

500-1000 mg

Daily

◆

How it works

Triterpenoids drive Gotu Kola effects:

Collagen Synthesis

Asiaticoside upregulates fibroblast collagen production - basis of wound healing and skin applications.

Capillary Stabilization

Strengthens venous walls and microcirculation - mechanism for venous insufficiency.

Cognitive

Asiatic acid neuroprotective in animal models; modest cognitive effects in older adults.

Anxiolytic

Mild GABAergic modulation; reduces anxiety in clinical trials.

Anti-Inflammatory

NF-κB modulation.

What to expect

Early

Days 1–7

Days 1-14: minimal subjective change.

Mid

Weeks 2–4

Weeks 4-12: peak effects.

Later

Weeks 4–12

Long-term continuous use OK.

Evidence

HumanPresent

AnimalStrong

In-vitroPresent

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

Evidence boundary from the checked abstract: In conclusion, multicomponent exercise training with or without the supplement Gotu kola improves cognitive function, inflammation, and oxidative stress in older adults with MCI.

In conclusion, multicomponent exercise training with or without the supplement Gotu kola improves cognitive function, inflammation, and oxidative stress in older adults with MCI.

Does Gotu kola supplementation improve cognitive function, inflammation, and oxidative stress more than multicomponent exercise alone? - a randomized controlled study. Journal of exercise rehabilitation · 2022 · PMID 36420467

Evidence scope. This entry supports only the exact statement quoted from the live abstract; it does not independently verify OnePin's displayed dose, route, frequency, formulation, population, or broader mechanism.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: 500mg-1g oral daily; Oral capsule, powder, or topical; 1-2x daily oral; topical as formulated. No checked live PubMed abstract verified this exact displayed dose, route, and frequency for the same molecule/formulation and relevant population.

Primary safety claim: No primary safety text present in source JSON. No checked live PubMed abstract directly verified this source-JSON safety claim at the displayed formulation, route, and regimen.

Side effects & safety

Commonly reported

Mild GI
Mild drowsiness

Less common & notes

Rare hepatotoxicity case reports - discontinue if jaundice or LFT elevation.
Allergic reactions rare.

Pharmacokinetics

Illustrative plasma concentration · 18 h

Half-life

Variable per triterpenoid

Peak · Tmax

1-3 hours

Elimination

Hours plasma; cumulative effects over weeks

Bioavailability

Oral moderate

Duration of action

Daily dosing for sustained effects

Clearance

Hepatic

Storage. Capsule/powder. Cool dry location.

Regulatory status

Dietary supplement (US, DSHEA). Traditional medicine in Asia.

Put it to work

Calculate, log & track

Open Gotu Kola straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Gotu Kola in the app →

Go deeper

The guide & community

The complete Gotu Kola walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

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