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OnePin Peptide Library · Cognitive & Mood

Cognitive & Mood Centella asiatica (Ayurvedic / TCM Herb)

Gotu Kola

Centella asiatica

Centella asiatica (Ayurvedic / TCM Herb)Cognitive / Venous Insufficiency / Wound HealingTriterpenoid (TECA) BotanicalDietary Supplement

Gotu Kola (Centella asiatica) is an Ayurvedic and TCM herb used for centuries for cognitive support, wound healing, and venous insufficiency. Active compounds: triterpenoids (asiaticoside, asiatic acid, madecassic acid, madecassoside) - the 'TECA' (Titrated Extract of Centella Asiatica) standardized form is the most-researched.

Quick Start
Route
Oral capsule, powder, or topical
Start low
500mg-1g oral daily
Frequency
1-2x daily oral; topical as formulated
Timing
With food

Independent.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
500mg-1g oral daily · Oral capsule, powder, or topical · 1-2x daily oral; topical as formulated
Lowest starting point. Hold about a week to assess tolerance before stepping up.
500mg-1g oral daily
1-2x daily oral; topical as formulated
Standard
Neuroprotection & Circulation
500-1000 mg · Oral · Daily
human clinical trial · Wattanathorn et al. 2008 (J Ethnopharmacol)
500-1000 mg
Daily
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01

How it works

Triterpenoids drive Gotu Kola effects:

Collagen Synthesis

Asiaticoside upregulates fibroblast collagen production - basis of wound healing and skin applications.

Capillary Stabilization

Strengthens venous walls and microcirculation - mechanism for venous insufficiency.

Cognitive

Asiatic acid neuroprotective in animal models; modest cognitive effects in older adults.

Anxiolytic

Mild GABAergic modulation; reduces anxiety in clinical trials.

Anti-Inflammatory

NF-κB modulation.

02

What to expect

Early
Days 1–7

Days 1-14: minimal subjective change.

Mid
Weeks 2–4

Weeks 4-12: peak effects.

Later
Weeks 4–12

Long-term continuous use OK.

03

Evidence

HumanPresent
AnimalStrong
In-vitroPresent
2000Centella asiatica: a review of pharmacological effects and clinical applications · Brinkhaus B et al, Phytomedicine ↗review
1990Total triterpenic fraction of Centella asiatica in chronic venous insufficiency · Belcaro G et al, Angiology ↗peer reviewed
2008Effects of Centella asiatica on cognition · Wattanathorn J et al, Journal of Ethnopharmacology ↗peer reviewed
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

05

Side effects & safety

Commonly reported

  • Mild GI
  • Mild drowsiness

Less common & notes

  • Rare hepatotoxicity case reports - discontinue if jaundice or LFT elevation.
  • Allergic reactions rare.
06

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
Variable per triterpenoid
Peak · Tmax
1-3 hours
Elimination
Hours plasma; cumulative effects over weeks
Activity
Daily dosing for sustained effects

Storage. Capsule/powder. Cool dry location.

07

Regulatory status

Dietary supplement (US, DSHEA). Traditional medicine in Asia.

Put it to work

Calculate, log & track

Open Gotu Kola straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Gotu Kola in the app →

Go deeper

The guide & community

The complete Gotu Kola walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
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