OnePin Peptide Library · Repair & Recovery
Thymosin Beta-4 Full
TB4 Full · Thymosin Beta-4 Full Length
Thymosin Beta-4 (TB4) is a naturally occurring 43-amino acid peptide that is the most abundant member of the beta-thymosin family. Originally isolated from the thymus gland by Allan Goldstein in the 1960s-70s, TB4 is now known to be expressed in virtually all nucleated cells throughout the body. It is the primary intracellular G-actin sequestering peptide, playing a fundamental role in actin cytoskeleton dynamics, cell motility, and tissue repair.,Unlike its truncated fragment TB-500 (which contains the active 17-amino acid sequence Ac-SDKP and surrounding residues), full-length Thymosin Beta-4 includes the complete native protein with all of its biological domains. TB4 promotes wound healing through multiple mechanisms including cell migration, angiogenesis, reduction of inflammation, and prevention of apoptosis. It also has cardioprotective properties and promotes hair follicle growth.,Thymosin Beta-4 is not currently FDA-approved for any indication, though it has been the subject of clinical trials for wound healing (particularly corneal wounds and cardiac repair after myocardial infarction). RegeneRx Biopharmaceuticals developed RGN-259 (TB4 eye drops) which showed positive Phase II results for neurotrophic keratopathy. The full-length peptide is available as a research compound.
Same timing as TB-500. Any time of day, no fasting required.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Sequesters G-actin monomers to regulate actin polymerization, controlling cytoskeletal dynamics essential for cell migration, wound closure, and tissue remodeling. The N-terminal tetrapeptide Ac-SDKP has potent anti-inflammatory and anti-fibrotic properties.,Promotes angiogenesis by upregulating VEGF and stimulating endothelial cell migration and tube formation. Also activates cardiac progenitor cells and promotes cardiomyocyte survival after ischemic injury via Akt/PI3K signaling pathway.,Reduces inflammation by downregulating NF-kB-mediated inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and promotes anti-inflammatory macrophage (M2) polarization. Inhibits apoptosis in damaged cells via activation of survival signaling pathways.
Sequesters G-actin monomers to regulate actin polymerization, controlling cytoskeletal dynamics essential for cell migration, wound closure, and tissue remodeling. The N-terminal tetrapeptide Ac-SDKP has potent anti-inflammatory and anti-fibrotic properties.,Promotes angiogenesis by upregulating VEGF and stimulating endothelial cell migration and tube formation. Also activates cardiac progenitor cells and promotes cardiomyocyte survival after ischemic injury via Akt/PI3K signaling pathway.,Reduces inflammation by downregulating NF-kB-mediated inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and promotes anti-inflammatory macrophage (M2) polarization. Inhibits apoptosis in damaged cells via activation of survival signaling pathways.
What to expect
Days 1-7: Anti-inflammatory effects begin. Reduced pain and swelling at injury sites. Cellular migration and early angiogenesis initiated.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Store refrigerated at 2-8C. Reconstituted solution should be used within 14-28 days. Protect from light.
Regulatory status
Not FDA-approved. Investigational new drug for corneal wound healing (RGN-259). Research compound for all other applications. WADA prohibited substance.
Put it to work
Calculate, log & track
Open Thymosin Beta-4 Full straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Thymosin Beta-4 Full in the app →Go deeper
The guide & community
The complete Thymosin Beta-4 Full walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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