OnePin Peptide Library · Hormonal
Progesterone Cream
Bioidentical Progesterone · Topical Progesterone
Transdermal bioidentical progesterone cream delivers progesterone through the skin, with the active metabolite allopregnanolone driving its characteristic GABAergic sedating effect. Cream-based (NOT a patch), typically applied daily to soft skin areas. Commonly compounded at 20, 50, or 100 mg per dose. In women with a uterus who are on systemic estrogen, progesterone is a non-optional adjunct to protect against endometrial hyperplasia. Evidence for transdermal progesterone's endometrial protection is weaker than oral micronized progesterone - discuss route with your prescriber.
Apply in the evening to inner thigh, forearm, or chest. Rotate sites daily to avoid receptor downregulation.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
Progesterone binds progesterone receptors (PR-A and PR-B) in uterine endometrium, breast, and CNS tissue. Its reduced metabolite allopregnanolone is a positive allosteric modulator of GABA-A receptors, producing anxiolytic and sedating effects - this is why evening dosing is preferred. Transdermal absorption varies widely between users and formulations (estimated 50-80% bioavailability), which is why transdermal progesterone's endometrial protection is considered less reliable than oral micronized progesterone.
Progesterone binds progesterone receptors (PR-A and PR-B) in uterine endometrium, breast, and CNS tissue. Its reduced metabolite allopregnanolone is a positive allosteric modulator of GABA-A receptors, producing anxiolytic and sedating effects - this is why evening dosing is preferred. Transdermal absorption varies widely between users and formulations (estimated 50-80% bioavailability), which is why transdermal progesterone's endometrial protection is considered less reliable than oral micronized progesterone.
What to expect
1-7 days: sleep improvement
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Side effects & safety
Commonly reported
- Drowsiness
- Breast tenderness (early)
- Mood changes
- Dizziness
Less common & notes
- Headache
- Nausea
- Application site irritation
- Unscheduled bleeding
Pharmacokinetics
Storage. Refrigerate compounded creams for best stability. Commercial creams stable at room temperature. Keep away from children and pets - skin contact can transfer hormone.
Regulatory status
Prescription-only when compounded. OTC progesterone creams (low-strength, bioidentical) are available but unregulated for content. FDA-approved oral micronized progesterone (Prometrium) is the preferred route for endometrial protection per most guidelines.
Put it to work
Calculate, log & track
Open Progesterone Cream straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open Progesterone Cream in the app →Go deeper
The guide & community
The complete Progesterone Cream walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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