OnePin Peptide Library · Longevity
N-Acetyl Epitalon
N-Acetyl Epithalon · NA-Epitalon · NA-Epithalon
N-Acetyl Epitalon (N-Ac-Epi) is the N-terminally acetylated form of Epitalon, a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by the St. Petersburg Institute of Bioregulation and Gerontology under Prof. Vladimir Khavinson. Native Epitalon is one of the original 'Cytogen' / 'Citamine' synthetic peptides modeled on naturally-occurring tissue-specific bioregulators isolated from animal organs (in this case, the pineal gland). The N-acetylation modification was introduced to improve bioavailability and metabolic stability vs the native peptide.
Russian convention: 10-20 day pulse cycles, repeat every 6 months. Evening dosing common (pineal/melatonin alignment). Reconstitute bac water; refrigerate.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
N-Acetyl Epitalon's putative mechanism centers on pineal-targeted peptide biology characteristic of the Russian Cytogen family:
Telomerase Activation (Russian Reports)
Russian publications report telomerase activity upregulation in fibroblast cell cultures with Epitalon/N-Ac-Epi treatment - the basis of telomere/longevity claims.
Pineal Gland Modulation
Epitalon and N-Ac-Epi are reported to enhance melatonin synthesis and normalize circadian rhythm in aged animals - related to the pineal-targeted bioregulator framework.
N-Acetylation Stability
The N-terminal acetyl group resists aminopeptidase degradation, extending plasma half-life from native Epitalon's very short (~30 min) to N-Ac-Epi's ~3-5 hours.
Cytogen Framework
Russian peptide research views these short peptides as 'tissue-specific bioregulators' - putatively bind chromatin DNA and modulate gene expression in their target tissue (pineal, in this case). Western mechanistic validation is limited.
No Met or Cys
Linear short peptide without sulfur-containing residues - chemistry-compatible with copper-conjugated peptides like GHK-Cu.
What to expect
Days 1-7: subtle sleep effects.
Days 7-20: peak pulse effect.
Months post-pulse: putative longevity effects (uncharacterized in humans).
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Keep separate
Side effects & safety
Commonly reported
- Mild injection site reaction
- Possible mild headache
- Vivid dreams (pineal modulation)
Less common & notes
- Long-term safety not characterized.
- Theoretical telomerase activation concerns in active malignancy or pre-malignancy contexts.
- Allergic reactions rare.
- Russian peptide class has good safety profile in published literature but Western validation is limited.
Pharmacokinetics
Storage. Refrigerate. Reconstituted: 21-28 days. Light-sensitive.
Regulatory status
Not FDA-approved. Available in Russian Federation as research/nutraceutical compound. Western use is research-chemical only.
Put it to work
Calculate, log & track
Open N-Acetyl Epitalon straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open N-Acetyl Epitalon in the app →Go deeper
The guide & community
The complete N-Acetyl Epitalon walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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