Metabolic Dietary supplement

Green Tea Extract (EGCG)

EGCG · Camellia sinensis Extract

Evidence: Community / limited published evidence. Example dose: finalize with a provider. Not a fact-check stamp.

200-400mg EGCG – 400-800 mg Oral 1-2x daily

Oral only. Standardized to 45-50% EGCG typically. Cardioprotective, anti-inflammatory, thermogenic. Caffeine-containing (unless decaf) - dose calculation needed if stacking with coffee. HEPATOTOXICITY WARNING at high doses on empty stomach - take WITH FOOD. Avoid if liver impairment. CYP3A4 mild inhibition.

Quick Start

Route

Oral capsule

Start low

200-400mg Oral

Frequency

1-2x daily

Timing

MANDATORY with food (hepatotoxicity risk on empty stomach)

With meals, AM or split AM/PM

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first

Conservative start

200-400mg EGCG · Oral capsule · 1-2x daily

conservative starter

200-400mg EGCG

1-2x daily

Standard

Metabolic Enhancement

400-800 mg · Oral · Daily

human clinical trial · Dulloo et al. 1999 (Am J Clin Nutr)

Avoid taking on a completely empty stomach to prevent nausea. High doses on an empty stomach carry rare risks of hepatotoxicity.

400-800 mg

Daily

◆

What to expect

Early

Days 1–7

First days to weeks: any focus or energy lift comes from caffeine content and is felt acutely; antioxidant effects are not something you feel.

Mid

Weeks 2–4

Weeks 4-8: metabolic and antioxidant support accrues with consistent daily use alongside diet and activity.

Later

Weeks 4–12

Ongoing: a long-game supportive supplement; benefits are maintenance-oriented rather than escalating.

Evidence

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

Evidence boundary from the checked abstract: Epigallocatechin gallate (EGCG), a typical flavone-3-ol polyphenol containing eight free hydroxyl groups, is associated with a variety of bioactivities, such as antioxidant, anti-inflammatory, anti-cancer, and antibacterial activities.

Epigallocatechin gallate (EGCG), a typical flavone-3-ol polyphenol containing eight free hydroxyl groups, is associated with a variety of bioactivities, such as antioxidant, anti-inflammatory, anti-cancer, and antibacterial activities.

Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate. Critical reviews in food science and nutrition · 2024 · PMID 36728926

Evidence scope. This entry supports only the exact statement quoted from the live abstract; it does not independently verify OnePin's displayed dose, route, frequency, formulation, population, or broader mechanism.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: 200-400mg EGCG; Oral capsule; 1-2x daily. No checked live PubMed abstract verified this exact displayed dose, route, and frequency for the same molecule/formulation and relevant population.

Primary safety claim: No primary safety text present in source JSON. No checked live PubMed abstract directly verified this source-JSON safety claim at the displayed formulation, route, and regimen.

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

Documented together

CurcuminComplementary anti-inflammatory polyphenols. Classic longevity stack.

FisetinBoth polyphenol class. Complementary senolytic/antioxidant.

L-TheanineGreen tea naturally contains both - clinical studies use EGCG+L-theanine combo for cognition.

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

Pharmacokinetics

Illustrative plasma concentration · 22 h

Half-life

~5 hours

Peak · Tmax

1-2 hours

Bioavailability

Low (~20% for EGCG); enhanced with phospholipids

Duration of action

6-8 hours

Polyphenol effect

Clearance

Hepatic glucuronidation, biliary

Storage. Oral capsule. ALWAYS take with food to reduce hepatotoxicity risk. Store at room temperature away from light. Some products now decaffeinated.

Put it to work

Calculate, log & track

Open Green Tea Extract (EGCG) straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Green Tea Extract (EGCG) in the app →

Go deeper

The guide & community

The complete Green Tea Extract (EGCG) walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

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