OnePin Peptide Library · Metabolic
Aged Garlic Extract (Kyolic)
Kyolic · AGE Garlic
Aged Garlic Extract (AGE) is produced by aging fresh garlic (Allium sativum) in 15-20% ethanol for 18-20 months under controlled conditions. This aging process converts the harsh, pungent allicin (responsible for fresh garlic's smell and GI irritation) into stable, water-soluble organosulfur compounds - primarily S-allyl cysteine (SAC), S-allyl mercaptocysteine (SAMC), and various sulfides. The result is an odorless, non-irritating, more bioavailable form of garlic with significantly enhanced cardiovascular research base.,AGE has the strongest clinical evidence among garlic preparations. The Kyolic brand (Wakunaga of America) is the most-studied AGE, with over 750 published research papers. Major trials have demonstrated AGE reverses coronary artery calcium progression, reduces blood pressure, improves vascular elasticity, modulates lipid profile, and supports immune function. The LARRY/LANCER cardiology RCTs are landmark studies for AGE in cardiovascular prevention.,Critical distinction: AGE is dramatically different from fresh garlic, garlic powder, or garlic oil. Most studies showing cardiovascular benefit use specifically AGE (Kyolic-type preparations). Other garlic supplements may have minimal or different effects. Generic 'garlic extract' should not be assumed equivalent.
Take with meals (improves tolerability and absorption). Split dosing (1,200mg AM + 1,200mg PM) is the LANCER trial protocol. AGE is odorless - no garlic breath unlike fresh garlic. Effects develop over 6-12 months for cardiac outcomes.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
S-allyl cysteine (SAC) is the primary bioavailable active component of AGE. SAC supports nitric oxide bioavailability (improving endothelial function and vasodilation), inhibits ACE (angiotensin-converting enzyme - similar to ACE inhibitor BP medications, though weaker), and provides antioxidant activity.,Plaque modulation: AGE may slow progression of coronary artery calcification (CAC) and promote regression of unstable, lipid-rich heterogeneous plaque. Mechanisms include endothelial protection, anti-inflammatory effects, and reduced LDL oxidation. The LARRY (Los Angeles Atherosclerosis) trials and subsequent LANCER trial demonstrated reduced CAC progression with AGE.,BP reduction: Mild ACE inhibition + improved NO availability + reduced oxidative stress in vasculature contribute to modest BP reduction (~5-10 mmHg systolic in hypertensive individuals).,Antioxidant: AGE contains potent antioxidants that reduce LDL oxidation (the atherogenic form of LDL) and protect endothelium from oxidative damage.,Anti-inflammatory: Reduces inflammatory markers (CRP, IL-6, TNF-alpha) relevant to atherosclerosis progression.,Platelet function: Modest antiplatelet effect (mild reduction in platelet aggregation) - contributes to cardiovascular benefit but rare bleeding risk at typical doses.,Lipid modulation: Modest reductions in total cholesterol, LDL, and triglycerides (effect smaller than statins or BPF).,Immune support: AGE enhances NK cell activity, T-cell function, and macrophage activity. May reduce cold/flu duration.
S-allyl cysteine (SAC) is the primary bioavailable active component of AGE. SAC supports nitric oxide bioavailability (improving endothelial function and vasodilation), inhibits ACE (angiotensin-converting enzyme - similar to ACE inhibitor BP medications, though weaker), and provides antioxidant activity.,Plaque modulation: AGE may slow progression of coronary artery calcification (CAC) and promote regression of unstable, lipid-rich heterogeneous plaque. Mechanisms include endothelial protection, anti-inflammatory effects, and reduced LDL oxidation. The LARRY (Los Angeles Atherosclerosis) trials and subsequent LANCER trial demonstrated reduced CAC progression with AGE.,BP reduction: Mild ACE inhibition + improved NO availability + reduced oxidative stress in vasculature contribute to modest BP reduction (~5-10 mmHg systolic in hypertensive individuals).,Antioxidant: AGE contains potent antioxidants that reduce LDL oxidation (the atherogenic form of LDL) and protect endothelium from oxidative damage.,Anti-inflammatory: Reduces inflammatory markers (CRP, IL-6, TNF-alpha) relevant to atherosclerosis progression.,Platelet function: Modest antiplatelet effect (mild reduction in platelet aggregation) - contributes to cardiovascular benefit but rare bleeding risk at typical doses.,Lipid modulation: Modest reductions in total cholesterol, LDL, and triglycerides (effect smaller than statins or BPF).,Immune support: AGE enhances NK cell activity, T-cell function, and macrophage activity. May reduce cold/flu duration.
What to expect
Weeks 1-4: Immune support, subtle BP changes.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Safe & synergistic
Keep separate
Pharmacokinetics
Storage. Store at room temperature (15-30C) in a cool, dry place. Protect from heat. Capsules and tablets shelf-stable 2-3 years.
Regulatory status
Classified as a dietary supplement in the US - no prescription required. Widely available. Kyolic brand has been on US market since 1955 with extensive safety record. No FDA-approved medical indication.
Put it to work
Calculate, log & track
Open Aged Garlic Extract (Kyolic) straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
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The guide & community
The complete Aged Garlic Extract (Kyolic) walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
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