library.onepin.app/l-theanine Peptide Education Library
Education only, not medical advice 21+ Every dose is an example to finalize with a licensed provider
Cognitive & Mood Dietary supplement

L-Theanine

Theanine · Suntheanine

100-200mg – 200 mg Oral 1-2x daily or as needed

Oral only. Amino acid from green tea. GABA-A positive modulator + increases alpha brain waves (calm focus without sedation). Classic caffeine pairing (1:2 ratio) smooths caffeine jitters. Very safe profile. No major drug interactions. Take anytime; evening dose supports sleep onset.

Quick Start
Route
Oral capsule
Start low
100-200mg Oral
Frequency
1-2x daily or as needed
Timing
Any time, with or without food

Morning with caffeine for focus, or 30 min pre-bed for sleep

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Conservative start
100-200mg · Oral capsule · 1-2x daily or as needed
conservative starter
100-200mg
1-2x daily or as needed
Standard
Focus & Calm
200 mg · Oral · As needed
human clinical trial · Kelly et al. 2008 (J Nutr)
Standard ratio is 2:1 L-Theanine to Caffeine for optimal focus.
200 mg
As needed
01

What to expect

Early
Days 1–7

30 to 60 minutes: the hallmark calm-focus effect is acute and felt the same dose, especially noticeable stacked with caffeine.

Mid
Weeks 2–4

Weeks 1-4: with regular use, day-to-day stress reactivity and sleep onset may improve.

Later
Weeks 4–12

Ongoing: a stable, non-escalating benefit that works well as an as-needed or daily tool.

02

Evidence

Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.

Evidence boundary from the checked abstract: L-theanine was found to be a safe and well-tolerated medication.

L-theanine was found to be a safe and well-tolerated medication.

L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. The Journal of clinical psychiatry · 2011 · PMID 21208586

Evidence scope. This entry supports only the exact statement quoted from the live abstract; it does not independently verify OnePin's displayed dose, route, frequency, formulation, population, or broader mechanism.

Claims we could not support

No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.

Dose/route: 100-200mg; Oral capsule; 1-2x daily or as needed. No checked live PubMed abstract verified this exact displayed dose, route, and frequency for the same molecule/formulation and relevant population.

Primary safety claim: No primary safety text present in source JSON. No checked live PubMed abstract directly verified this source-JSON safety claim at the displayed formulation, route, and regimen.

03

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

Documented together

ApigeninComplementary GABA-ergic + alpha wave synergy for calm focus and sleep onset.
Magnesium GlycinateStacked evening sleep protocol - GABA modulation + glycine delivery.
GlycineBoth glycinergic calming effects. Well-tolerated combination.
MelatoninSleep onset support via different mechanisms (alpha waves + circadian signaling).

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

04

Pharmacokinetics

Illustrative plasma concentration · 5 h
Half-life
~1 hour
Peak · Tmax
40-50 min
Bioavailability
~90%

Oral

Duration of action
2-4 hours

Calming effect

Clearance

Hepatic/renal

Storage. Oral capsule/powder. Store at room temperature.

Put it to work

Calculate, log & track

Open L-Theanine straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open L-Theanine in the app →

Go deeper

The guide & community

The complete L-Theanine walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
Open in app Community

Track it in OnePin. Log vials, draws, and protocols in the app.