OnePin Peptide Library · Cognitive & Mood
CBD
Cannabidiol
CBD (Cannabidiol) is a non-psychoactive cannabinoid from hemp/cannabis. Distinct from THC - CBD does NOT bind CB1 receptors directly and produces no intoxication. Acts via multiple targets: weak partial agonist at CB1/CB2, allosteric modulator of CB1/CB2, agonist at TRPV1, 5-HT1A receptor agonist, and inhibitor of FAAH (fatty acid amide hydrolase, which raises endogenous anandamide).
Divided doses or evening for sleep.
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
How it works
CBD has a polypharmacology profile:
CB1/CB2 Allosteric Modulation
Negative allosteric modulator at CB1 - reduces THC's psychoactive effects (basis of CBD/THC ratio products). CB2 partial agonist - peripheral anti-inflammatory.
FAAH Inhibition
Inhibits fatty acid amide hydrolase, raising endogenous anandamide - indirect endocannabinoid system enhancement.
5-HT1A Agonism
Direct serotonin receptor agonism contributes to anxiolytic effects.
TRPV1 Agonism
Vanilloid receptor activation contributes to pain and inflammation modulation.
Adenosine Reuptake Inhibition
Raises adenosine, contributing to anti-inflammatory and sleep effects.
CYP450 Inhibition
CBD inhibits CYP3A4 and CYP2C9 at higher doses - drug interactions are real and important. Notable: CBD significantly affects warfarin INR.
What to expect
Acute 30-90 min onset (sublingual).
Weeks 1-4: peak effects.
Long-term continuous use OK.
Evidence
Interactions & stacking
What's safe to combine, and what belongs in a separate pin.
Keep separate
Side effects & safety
Commonly reported
- Mild drowsiness
- Mild dry mouth
- Mild GI
Less common & notes
- Hepatic enzyme elevation at high doses (especially with valproate).
- Drug interactions via CYP inhibition.
- Rare allergic reactions.
- Long-term safety at typical doses appears favorable.
Pharmacokinetics
Storage. Oil/capsule. Cool dry location, refrigerate after opening. Light-sensitive.
Regulatory status
FDA-approved as Epidiolex for select pediatric epilepsy syndromes. Hemp-derived CBD with <0.3% THC sold as dietary supplement post-2018 Farm Bill (US). State laws vary. Marijuana-derived CBD is federally controlled.
Put it to work
Calculate, log & track
Open CBD straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.
Open CBD in the app →Go deeper
The guide & community
The complete CBD walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.
Join the community ↗