library.onepin.app/pycnogenol Peptide Education Library
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OnePin Peptide Library · Cardiovascular

Cardiovascular French Maritime Pine Bark Extract

Pycnogenol

French Maritime Pine Bark · Maritime Pine Extract

French Maritime Pine Bark ExtractProcyanidin / OPC AntioxidantCardiovascular / Skin SupportDietary Supplement (Patented)

Pycnogenol is the proprietary trade name for French maritime pine bark extract (Pinus pinaster), standardized to 65-75% procyanidins. Procyanidins are oligomeric proanthocyanidins (OPCs) - powerful antioxidants and nitric oxide modulators with cardiovascular, cognitive, and skin benefits.

Quick Start
Route
Oral capsule
Start low
50-100mg daily
Frequency
1-2x daily
Timing
With food

With meals.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
50-100mg daily · Oral capsule · 1-2x daily
Lowest starting point. Hold about a week to assess tolerance before stepping up.
50-100mg daily
1-2x daily
Standard
Circulation & Antioxidant
100 mg · Oral · Daily
human clinical trial · Luzzi, Belcaro et al. 2011 (Panminerva Med 53(3 Suppl 1):75-82; PMID 22108481)
100 mg
Daily
◆
01

How it works

Pycnogenol procyanidins act through:

Antioxidant

Direct ROS scavenging plus glutathione system support.

NO Modulation

Enhances eNOS activity and protects NO from oxidative degradation - cardiovascular and erectile mechanisms.

Anti-Inflammatory

NF-κB pathway modulation reduces inflammatory cytokines.

Capillary Stabilization

Strengthens capillary walls; reduces edema in venous insufficiency.

Procyanidin-Specific

Higher polymerization index than other OPC sources - bioavailability profile differs from grape seed extract or cocoa procyanidins.

02

What to expect

Early
Days 1–7

Days 1-14: subtle subjective effects.

Mid
Weeks 2–4

Weeks 4-12: peak effects.

Later
Weeks 4–12

Long-term continuous use OK.

03

Evidence

HumanStrong
AnimalStrong
In-vitroPresent
2014Pycnogenol in chronic venous insufficiency and related venous disorders · Gulati OP, Phytotherapy Research ↗review
2015Prelox: a randomized, double-blind, placebo-controlled trial of Pycnogenol-L-Arginine combination for erectile dysfunction · Stanislavov R, Rohdewald P, Journal of Sexual Medicine ↗peer reviewed
2002Antioxidative properties of pine bark extract · Rohdewald P, International Journal of Clinical Pharmacology and Therapeutics ↗review
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

05

Side effects & safety

Commonly reported

  • Mild GI
  • Mild dizziness rare

Less common & notes

  • Mild antiplatelet activity.
  • Allergic reactions rare.
  • Long-term safety good per extensive clinical use.
06

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
~5-14 hours (multi-component)
Peak · Tmax
1-3 hours
Elimination
Days for cumulative effects
Activity
Daily dosing for sustained effects

Storage. Capsule. Cool dry location.

07

Regulatory status

Dietary supplement (US, DSHEA). Patented by Horphag Research.

Put it to work

Calculate, log & track

Open Pycnogenol straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Pycnogenol in the app →

Go deeper

The guide & community

The complete Pycnogenol walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
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