library.onepin.app/serrapeptase Peptide Education Library
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Education only, not medical advice◆ 21+◆ Every dose is an example to finalize with a licensed provider

OnePin Peptide Library · Gut & Digestion

Gut & Digestion Bacterial Proteolytic Enzyme (Serratia E-15)

Serrapeptase

Serratiopeptidase · Serratia E-15

Bacterial Proteolytic Enzyme (Serratia E-15)Mucolytic / Anti-InflammatoryPharmaceutical (Asia/Europe) / Supplement (US)Acid-Labile (Enteric Coating Required)

Serrapeptase (Serratiopeptidase) is a proteolytic enzyme originally isolated from the silkworm gut bacterium Serratia E-15 (now produced via fermentation). Used in Asia and Europe since the 1960s for inflammation, pain, and mucolytic applications. Available as pharmaceutical drug in Japan, Italy, and other countries; sold as dietary supplement in the US.

Quick Start
Route
Oral enteric-coated tablet
Start low
60,000-120,000 SU daily
Frequency
1-3x daily
Timing
Empty stomach (30-60 min before meals or 2 hours after)

Empty stomach essential.

❋

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Quick Start
Conservative start
60,000-120,000 SU daily · Oral enteric-coated tablet · 1-3x daily
Lowest starting point. Hold about a week to assess tolerance before stepping up.
60,000-120,000 SU daily
1-3x daily
Standard
Systemic Anti-Inflammatory
10-30 mg · Oral · Daily
human clinical trial · Mazzone et al. 1990 (J Int Med Res; PMID 2257960)
10-30 mg
Daily
◆
01

How it works

Serrapeptase is a 30 kDa metalloprotease:

Mucolytic

Hydrolyzes mucus glycoproteins, thinning thick mucus secretions in sinusitis, bronchitis, cystic fibrosis.

Anti-Inflammatory

Hydrolyzes bradykinin, fibrin, and inflammatory exudates - reduces edema and pain.

Fibrinolytic

Breaks down fibrin (cross-linked protein) - mechanism for proposed cardiovascular plaque effects.

Enteric Coating Critical

Stomach acid degrades serrapeptase. Enteric-coated tablets release in the alkaline small intestine for absorption.

Selective Action

Acts on dead/damaged tissue but spares healthy tissue - mechanism for safety profile.

02

What to expect

Early
Days 1–7

Days 1-7: acute anti-inflammatory effects.

Mid
Weeks 2–4

Weeks 1-4: peak effects.

Later
Weeks 4–12

Long-term: as needed.

03

Evidence

HumanPresent
AnimalPresent
In-vitroPresent
2013Serrapeptase: a clinically useful proteolytic enzyme · Bhagat S et al, Reviews on Recent Clinical Trials ↗review
1990Treatment of acute or chronic ear, nose and throat inflammatory pathology with Serratiopeptidase · Mazzone A et al, Drugs Under Experimental and Clinical Research ↗peer reviewed
04

Interactions & stacking

What's safe to combine, and what belongs in a separate pin.

Keep separate

05

Side effects & safety

Commonly reported

  • Mild GI
  • Mild headache rare

Less common & notes

  • BLEEDING RISK with anticoagulants.
  • Allergic skin reactions.
  • Long-term safety good in non-bleeding contexts.
06

Pharmacokinetics

Illustrative plasma concentration · 24 h
Half-life
Hours plasma
Peak · Tmax
2-4 hours post-ingestion (enteric)
Elimination
Hours plasma; cumulative effects over weeks
Activity
Daily dosing for sustained effects

Storage. Tablet. Cool dry location, refrigerate for extended storage.

07

Regulatory status

Dietary supplement (US, DSHEA). Pharmaceutical drug in Japan, India, other Asian markets. EMA / Italy withdrew pharmaceutical status 2014.

Put it to work

Calculate, log & track

Open Serrapeptase straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Serrapeptase in the app →

Go deeper

The guide & community

The complete Serrapeptase walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
Open in app Community